Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.57 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | RORA | P35398 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | RORB | Q92753 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735956 | 0.76 | NOTUM (0.62) | NOTUMDAOALDH1A1LMNAMAPT | |
| SCHEMBL9844700 | 0.76 | NOTUM (0.62) | NOTUMPLA2G10CYP1A2CYP2A6DAO | |
| SCHEMBL946355 | 0.76 | NOTUM (0.62) | NOTUMCYP2A6ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL30615209 | 0.73 | NOTUM (1.00) | NOTUMDAOALDH1A1MAPTKDM4E | |
| SCHEMBL946554 | 0.72 | NOTUM (0.57) | NOTUM | |
| SCHEMBL9844702 | 0.69 | NOTUM (0.62) | NOTUMCYP1A2CYP2A6DAONPC1 | |
| SCHEMBL9261564 | 0.66 | NOTUM (0.57) | NOTUMCYP1A2CYP2A6ALDH1A1SMN1; SMN2 | |
| SCHEMBL763376 | 0.65 | BRPF1 (0.53) | CYP1A2CYP2A6DAOHTR7PGR | |
| SCHEMBL7006777 | 0.65 | HTR7 (0.39) | PLA2G10PLA2G2ACYP1A2CYP2A6DAO | |
| SCHEMBL31425886 | 0.65 | BRPF1 (0.49) | CYP1A2CYP2A6DAOHTR7PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992021678-A1 | LIPOXYGENASE INHIBITING PYRROLO [1,2a]INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-10 | — | — | WO | disclosed |