Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9261010 | 0.89 | PPARG (0.51) | NPC1RAB9APPARGPPARAGFER | |
| SCHEMBL9005931 | 0.79 | ATP4A (0.41) | RAB9ATP53MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL9261216 | 0.79 | ALDH1A1 (0.55) | NPC1RAB9APPARGPPARATP53 | |
| SCHEMBL9263830 | 0.78 | PPARA (0.51) | NPC1RAB9APPARGPPARATP53 | |
| SCHEMBL9178076 | 0.78 | PPARA (0.66) | PPARGPPARATP53SCN9AKCNH2 | |
| SCHEMBL9263153 | 0.78 | NPC1 (0.53) | NPC1RAB9APPARGPPARAGFER | |
| SCHEMBL9260695 | 0.77 | TP53 (0.52) | NPC1RAB9APPARGPPARATP53 | |
| SCHEMBL9258919 | 0.76 | PPARG (0.53) | PPARGPPARATP53ALOX5LMNA | |
| SCHEMBL9263735 | 0.74 | NPC1 (0.54) | NPC1RAB9APPARGPPARAGFER | |
| SCHEMBL9259687 | 0.74 | KDM4E (0.52) | NPC1RAB9APPARGPPARATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459154-A | Enzyme inhibitors as antiinflammatory agents and treatment of atherosclerosis | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-10-17 | — | — | US | claimed |
| US-5459154-A | Enzyme inhibitors as antiinflammatory agents and treatment of atherosclerosis | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-10-17 | — | — | US | disclosed |