Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9262328 | 0.88 | KDM4E (0.55) | NPC1RAB9ATP53LMNAMAPT | |
| SCHEMBL9257856 | 0.88 | ALDH1A1 (0.50) | NPC1RAB9ATP53LMNAMAPT | |
| SCHEMBL9177050 | 0.86 | PPARA (0.62) | TP53GFERMAPTPPARGPPARA | |
| SCHEMBL9266531 | 0.85 | TP53 (0.51) | TP53LMNAMAPTALOX5PPARG | |
| SCHEMBL9263735 | 0.79 | NPC1 (0.54) | NPC1RAB9ATP53GFERLMNA | |
| SCHEMBL9253236 | 0.79 | ALOX5 (0.52) | NPC1RAB9ATP53GFERLMNA | |
| SCHEMBL9253242 | 0.79 | ALOX5 (0.52) | NPC1RAB9ATP53GFERLMNA | |
| SCHEMBL9261010 | 0.78 | PPARG (0.51) | NPC1RAB9ATP53GFERLMNA | |
| SCHEMBL9265189 | 0.78 | NPC1 (0.50) | NPC1RAB9ATP53GFERLMNA | |
| SCHEMBL9178228 | 0.76 | PPARA (0.55) | NPC1RAB9ATP53LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459154-A | Enzyme inhibitors as antiinflammatory agents and treatment of atherosclerosis | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-10-17 | — | — | US | disclosed |