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Sugi Predict / Compounds / SCHEMBL9268386

SCHEMBL9268386

SCHEMBL9268386

COC(=O)N1CCC(n2cc(-c3ccc(F)cc3)c3cc(C)ccc32)CC1

nearest known ligand 0.70

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ ASH1L Q9NR48 1/20 0.43
▸ KDM1A O60341 2/20 0.43
▸ PKM P14618 1/20 0.41
▸ IRAK4 Q9NWZ3 1/20 0.39
▸ CHRM3 P20309 2/20 0.39
▸ DGAT2 Q96PD7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9272489 0.85 ABL1 (0.43) ASH1L
SCHEMBL9273497 0.82 ASH1L (0.44) ASH1L
SCHEMBL9265705 0.82 PLD2 (0.41) ASH1LCHRM3
SCHEMBL9272525 0.81 ASH1L (0.41) ASH1LCHRM3
SCHEMBL9270580 0.80 SLC2A1 (0.43) ASH1L
SCHEMBL9287294 0.80 PRKCG (0.42) ASH1L
SCHEMBL9287300 0.78 DRD2 (0.47) ASH1L
SCHEMBL9273642 0.78 KDM1A (0.41) ASH1LKDM1A
SCHEMBL9269584 0.78 CARM1 (0.43) ASH1L
SCHEMBL9268846 0.77 ASH1L (0.42) ASH1L

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5393761-A Treatment of nervous system disorders H. LUNDBECK A/S (DK) 1995-02-28 — — US disclosed
EP-0470039-B1 Novel 3-arylindole and 3-arylindazole derivatives LUNDBECK & CO AS H (DK) 1994-12-07 — — EP disclosed
EP-0470039-A2 Novel 3-arylindole and 3-arylindazole derivatives H. LUNDBECK A/S (DK) 1992-02-05 — — EP disclosed