Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | PLA2G4B | P0C869 | 4/20 | 0.55 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7756952 | 1.00 | TSHR (0.59) | TSHRPLA2G4BSMPD1LTA4HGGPS1 | |
| SCHEMBL9065935 | 1.00 | TSHR (0.59) | TSHRPLA2G4BSMPD1LTA4HGGPS1 | |
| SCHEMBL9065483 | 1.00 | TSHR (0.59) | TSHRPLA2G4BSMPD1LTA4HGGPS1 | |
| SCHEMBL7634664 | 1.00 | TSHR (0.59) | TSHRPLA2G4BSMPD1LTA4HGGPS1 | |
| SCHEMBL7282207 | 0.98 | TSHR (0.57) | TSHRPLA2G4BSMPD1LTA4HGGPS1 | |
| SCHEMBL3029634 | 0.93 | LTA4H (0.53) | TSHRPLA2G4BSMPD1LTA4HTHRB | |
| SCHEMBL910595 | 0.88 | KMT2A (0.54) | TSHRPLA2G4BLTA4H | |
| SCHEMBL6957299 | 0.84 | TSHR (0.59) | TSHRPLA2G4BSMPD1LTA4HTHRA | |
| SCHEMBL3680649 | 0.84 | TSHR (0.59) | TSHRPLA2G4BSMPD1LTA4HGGPS1 | |
| SCHEMBL6960220 | 0.84 | TSHR (0.59) | TSHRPLA2G4BSMPD1LTA4HTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995013266-A1 | ACYLPYRROLE-ALKANOIC ACIDS AND INDOLE-2-ALKANOIC ACIDS PLUS THEIR DERIVATIVES FOR USE AS INHIBITORS OF PHOSPHOLIPASE A¿2? | MERCKLE GMBH CHEM.-PHARM. FABRIK (DE) | 1995-05-18 | — | — | WO | disclosed |