Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | METAP1 | P53582 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29389300 | 1.00 | MAOA (0.56) | MAOAMAOBKDM4EALDH1A1METAP1 | |
| Bicarbonate SCHEMBL11023181 | 0.92 | MAOA (0.48) | MAOAMAOBKDM4EALDH1A1METAP1 | |
| SCHEMBL20319870 | 0.79 | MAOA (0.54) | MAOAMAOBKDM4EALDH1A1METAP1 | |
| SCHEMBL856788 | 0.79 | TDP1 (0.54) | MAOAMAOBKDM4EALDH1A1METAP1 | |
| SCHEMBL29461212 | 0.79 | TDP1 (0.54) | MAOAMAOBKDM4EALDH1A1METAP1 | |
| SCHEMBL29498049 | 0.79 | MAOA (0.39) | MAOAMAOBKDM4EALDH1A1METAP1 | |
| SCHEMBL28749614 | 0.79 | MAOA (0.39) | MAOAMAOBKDM4EALDH1A1METAP1 | |
| SCHEMBL17412365 | 0.78 | DHFR (0.51) | KDM4EALDH1A1TDP1GLAHPGD | |
| SCHEMBL516091 | 0.78 | TDP1 (0.59) | MAOAMAOBKDM4EALDH1A1METAP1 | |
| Benzoylenurea SCHEMBL7420432 | 0.78 | PARP1 (0.60) | KDM4EALDH1A1TDP1CASP7HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2108 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116640095-A | Diaryl amine derivative containing aliphatic carboxyl and preparation method and application thereof | 山东大学 | 2023-08-25 | — | — | CN | claimed |
| CN-114805223-B | 2, 4-disubstituted quinazoline compound for inhibiting EGFR, preparation method and application | 自贡市第四人民医院(自贡市急救中心) | 2023-05-09 | — | — | CN | claimed |
| CN-114805223-A | 2, 4-disubstituted quinazoline compound for inhibiting EGFR (epidermal growth factor receptor), and preparation method and application thereof | 自贡市第四人民医院(自贡市急救中心) | 2022-07-29 | — | — | CN | claimed |
| CN-108440500-B | Quinazoline HIV-1 inhibitor and preparation method and application thereof | 山东大学 | 2021-03-16 | — | — | CN | claimed |
| CN-111848585-A | 2, 4-disubstituted quinazoline derivative, preparation method thereof and application thereof in antitumor drugs | 陈爱平 | 2020-10-30 | — | — | CN | claimed |
| CN-108864057-B | JAK and HDAC double-target-point inhibitor containing 4-aminopyrazole structure and preparation method and application thereof | 山东大学 | 2020-03-31 | — | — | CN | claimed |
| CN-110526873-A | The benzo Diarylmiazines compound and its preparation method and application that acrylonitrile base replaces | UNIV FUDAN | 2019-12-03 | — | — | CN | claimed |
| CN-109182827-B | Chip LED encapsulation alloy bonding line and its manufacturing method | Henan grand Electronic Technology Co., Ltd. (CN) | 2019-10-29 | — | — | CN | claimed |
| CN-106518790-B | A kind of synthetic method of 2,4- dichloroquinazoline | 河南省商业科学研究所有限责任公司 | 2019-01-15 | — | — | CN | claimed |
| CN-109182827-A | Chip LED encapsulation alloy bonding line and its manufacturing method | 河南大仑电子科技有限公司 | 2019-01-11 | — | — | CN | claimed |
| WO-2004087053-A2 | DIPEPTIDYL PEPTIDASE INHIBITORS | SYRRX, INC. (US) | 2004-10-14 | — | — | WO | claimed |
| WO-1993010452-A1 | DIAGNOSIS REACTANT, ITS APPLICATIONS IN A METHOD FOR ASSAYING AN ANALYTE AND DEVICE FOR IMPLEMENTING SUCH METHOD | CLONATEC (FR) | 1993-05-27 | — | — | WO | claimed |
| EP-0542627-A1 | Diagnostic reagent, its applications in a method for determining an analyte and apparatus for carrying out this method | CLONATEC (FR) | 1993-05-19 | — | — | EP | claimed |
| EP-0167107-B1 | PROCESS FOR THE MANUFACTURE OF AQUEOUS, FLUID PREPARATIONS OF REACTIVE DYES WITH A LOW SALT CONTENT | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-05-08 | — | — | EP | claimed |
| CN-85105802-B | Process for preparing low-salt aqueous preparations of fibre-reactive dyes | 赫司特公司 | 1988-07-20 | — | — | CN | claimed |
| CN-85105802-A | The method of the less salt aqueous compositions of preparation fibre-reactive dye | — | 1987-01-28 | — | — | CN | claimed |
| EP-0167107-A2 | Process for the manufacture of aqueous, fluid preparations of reactive dyes with a low salt content | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-01-08 | — | — | EP | claimed |
| EP-0069300-B1 | LIQUID PREPARATIONS OF REACTIVE DYES AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-02-20 | — | — | EP | claimed |
| US-4443224-A | Liquid reactive dyestuff preparations and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-04-17 | — | — | US | claimed |
| EP-0069300-A1 | Liquid preparations of reactive dyes and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-01-12 | — | — | EP | claimed |