Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.59 |
| ▸ | MC4R | P32245 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11457324 | 0.85 | CHRNB2 (0.51) | SIGMAR1LMNAKDM4EALDH1A1TDP1 | |
| SCHEMBL7270268 | 0.80 | SIGMAR1 (0.61) | SIGMAR1MC4RDRD4LMNAPOLB | |
| SCHEMBL9232557 | 0.79 | SIGMAR1 (0.59) | SIGMAR1MC4RDRD4LMNAPOLB | |
| SCHEMBL17533384 | 0.77 | SIGMAR1 (0.57) | SIGMAR1MC4RDRD4LMNAPOLB | |
| SCHEMBL12493124 | 0.76 | SIGMAR1 (0.55) | SIGMAR1MC4RDRD4LMNAPOLB | |
| SCHEMBL11463836 | 0.76 | SIGMAR1 (0.55) | SIGMAR1MC4RDRD4LMNAPOLB | |
| SCHEMBL1415730 | 0.76 | SIGMAR1 (1.00) | SIGMAR1MC4RDRD4LMNAPOLB | |
| SCHEMBL576868 | 0.76 | SIGMAR1 (1.00) | SIGMAR1MC4RDRD4LMNAPOLB | |
| SCHEMBL8188324 | 0.76 | SIGMAR1 (1.00) | SIGMAR1MC4RDRD4LMNAPOLB | |
| SCHEMBL2489199 | 0.76 | SIGMAR1 (1.00) | SIGMAR1MC4RDRD4LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10022359-B2 | 1,9-diazaspiro undecane compounds having multimodal activity against pain | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2018-07-17 | — | — | US | disclosed |
| US-20170354648-A1 | 1,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2017-12-14 | — | — | US | disclosed |
| EP-2252149-B1 | A METHOD FOR THE PREPARATION OF FENTANYL | DIRECTOR GENERAL DEFENCE RES & DEV ORG (IN) | 2013-11-20 | — | — | EP | disclosed |
| US-8399677-B2 | Method for the preparation of fentanyl | DEFENCE RESEARCH & DEVELOPMENT ORGANISATION (IN) | 2013-03-19 | — | — | US | disclosed |
| US-20110021781-A1 | Method for the Preparation of Fentanyl | Director General Defence Research & Development Organization, Ministry of Defence (IN) | 2011-01-27 | — | — | US | disclosed |
| EP-2252149-A2 | A METHOD FOR THE PREPARATION OF FENTANYL | Director General, Defence Research & Development Organisation (IN) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009116084-A2 | A METHOD FOR THE PREPARATION OF FENTANYL | DIRECTOR GENERAL, DEFENCE RESEARCH & DEVELOPMENT ORGANISATION, MINISTRY OF DEFENCE (IN) | 2009-09-24 | — | — | WO | disclosed |
| US-5145967-A | Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and derivatives thereof | ANAQUEST, INC. (US) | 1992-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170354648-A1 | 1,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN | OPRD1, OPRM1, SIGMAR1 | SIGMAR1 3/4885MC4R 493/4885DRD4 71/4885 |
| US-10022359-B2 | 1,9-diazaspiro undecane compounds having multimodal activity against pain | OPRD1, OPRM1, SIGMAR1 | SIGMAR1 3/4885MC4R 493/4885DRD4 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.