Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | PLD2 | O14939 | 4/20 | 0.35 |
| ▸ | PLD1 | Q13393 | 4/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9279274 | 0.89 | ACACB (0.37) | DRD4PLD2PLD1CYP2D6 | |
| SCHEMBL9279426 | 0.89 | HRH3 (0.39) | DRD4TMEM97SIGMAR1GRIN2BMEN1 | |
| SCHEMBL9105132 | 0.88 | DRD4 (0.39) | DRD4TMEM97SIGMAR1GRIN2BMEN1 | |
| SCHEMBL9105136 | 0.88 | DRD4 (0.39) | DRD4TMEM97SIGMAR1GRIN2BMEN1 | |
| SCHEMBL9277120 | 0.86 | CHRM2 (0.39) | SIGMAR1MEN1KMT2AL3MBTL1ADRA1A | |
| SCHEMBL9280249 | 0.85 | DRD4 (0.37) | DRD4TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL9275957 | 0.85 | HRH3 (0.44) | HRH3CYP2D6 | |
| SCHEMBL9273443 | 0.82 | HRH3 (0.36) | DRD4GRIN2BMEN1KMT2AL3MBTL1 | |
| SCHEMBL9287812 | 0.82 | HTR7 (0.38) | DRD4GRIN2BMEN1KMT2AL3MBTL1 | |
| SCHEMBL9283497 | 0.80 | HDAC4 (0.36) | TMEM97SIGMAR1ADRA1AHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012074469-A1 | NEW IKACH BLOCKERS | ASTRAZENECA AB (SE) | 2012-06-07 | — | — | WO | disclosed |