Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9277120 | 0.86 | CHRM2 (0.39) | CYP2D6ADRA1AHTR1ASIGMAR1MAOA | |
| SCHEMBL9275813 | 0.85 | ALDH1A1 (0.37) | HDAC4CYP2D6CYP3A4SIGMAR1DRD3 | |
| SCHEMBL9280179 | 0.85 | HDAC4 (0.38) | HDAC4ADRA1AHTR1ADRD3USP2 | |
| SCHEMBL9275586 | 0.83 | HTR1A (0.40) | CYP2D6CYP3A4HTR1ADRD3USP2 | |
| SCHEMBL9275957 | 0.82 | HRH3 (0.44) | CYP2D6 | |
| SCHEMBL9279426 | 0.82 | HRH3 (0.39) | SIGMAR1TMEM97HTR7 | |
| SCHEMBL9273443 | 0.82 | HRH3 (0.36) | ADRA1AHTR1AMAOAMAOBMAPK14 | |
| SCHEMBL9287812 | 0.82 | HTR7 (0.38) | ADRA1AHTR1AMAOAMAOBMAPK14 | |
| SCHEMBL9279362 | 0.81 | HDAC8 (0.42) | HDAC4CYP2D6CYP3A4USP2ALDH1A1 | |
| SCHEMBL9288110 | 0.81 | MAOA (0.36) | HDAC4CYP2D6MAOAMAOBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012074469-A1 | NEW IKACH BLOCKERS | ASTRAZENECA AB (SE) | 2012-06-07 | — | — | WO | disclosed |