Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PLD2 | O14939 | 3/20 | 0.33 |
| ▸ | PLD1 | Q13393 | 3/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9100700 | 0.88 | DRD4 (0.37) | DRD4TMEM97SIGMAR1AVPR1BHRH3 | |
| SCHEMBL9100695 | 0.88 | DRD4 (0.37) | DRD4TMEM97SIGMAR1AVPR1BHRH3 | |
| SCHEMBL9279426 | 0.88 | HRH3 (0.39) | DRD4TMEM97SIGMAR1HRH3MEN1 | |
| SCHEMBL9277120 | 0.85 | CHRM2 (0.39) | SIGMAR1HRH3MEN1KMT2AL3MBTL1 | |
| SCHEMBL9279889 | 0.85 | DRD4 (0.39) | DRD4TMEM97SIGMAR1AVPR1BHRH3 | |
| SCHEMBL9275957 | 0.84 | HRH3 (0.44) | HRH3 | |
| SCHEMBL9287812 | 0.81 | HTR7 (0.38) | DRD4MEN1KMT2AL3MBTL1MAOA | |
| SCHEMBL9273443 | 0.81 | HRH3 (0.36) | DRD4HRH3MEN1KMT2AL3MBTL1 | |
| SCHEMBL9283497 | 0.79 | HDAC4 (0.36) | TMEM97SIGMAR1MAOAMAOBHTR7 | |
| SCHEMBL9100697 | 0.76 | HRH3 (0.39) | DRD4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012074469-A1 | NEW IKACH BLOCKERS | ASTRAZENECA AB (SE) | 2012-06-07 | — | — | WO | disclosed |