Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8596880 | 1.00 | POLB (0.34) | POLBSMN1; SMN2CXCR4SIGMAR1HSD17B10 | |
| SCHEMBL8596883 | 1.00 | POLB (0.34) | POLBSMN1; SMN2CXCR4SIGMAR1HSD17B10 | |
| SCHEMBL16853210 | 0.83 | ALOX15 (0.36) | — | |
| SCHEMBL175418 | 0.79 | POLB (0.35) | POLBSMN1; SMN2CXCR4SIGMAR1HSD17B10 | |
| SCHEMBL11669571 | 0.79 | CXCR4 (0.54) | POLBSMN1; SMN2CXCR4SIGMAR1 | |
| SCHEMBL28815065 | 0.75 | ALDH1A1 (0.33) | — | |
| SCHEMBL1481329 | 0.74 | POLB (0.35) | POLBSMN1; SMN2CXCR4SIGMAR1HSD17B10 | |
| SCHEMBL7710736 | 0.74 | SMN1; SMN2 (0.35) | POLBSMN1; SMN2CXCR4SIGMAR1HSD17B10 | |
| SCHEMBL7710694 | 0.74 | SIGMAR1 (0.38) | POLBSMN1; SMN2CXCR4SIGMAR1HSD17B10 | |
| SCHEMBL3404082 | 0.74 | SMN1; SMN2 (0.35) | POLBSMN1; SMN2CXCR4SIGMAR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5440048-A | Treating psychoses | HOECHST-ROUSSEL PHARMACEUTICALS INC (US) | 1995-08-08 | — | — | US | disclosed |
| US-5334715-A | For treating psychological disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-08-02 | — | — | US | disclosed |
| US-5194436-A | For trating psychosis | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-03-16 | — | — | US | disclosed |
| EP-0494604-A1 | 1-Piperazinyl-2-butenes and 2-butynes, intermediates thereof, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-15 | — | — | EP | disclosed |
| US-5130315-A | Treatment of psychosis | Wittekind, Raymond R. (US) | 1992-07-14 | — | — | US | disclosed |