Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9280556 | 0.77 | — | — | |
| SCHEMBL27150339 | 0.76 | CYP1A2 (0.36) | KMT2ALMNAMEN1ABCC4PKM | |
| SCHEMBL30503576 | 0.73 | KMT2A (0.38) | KMT2ALMNAMEN1ABCC4PKM | |
| SCHEMBL26631326 | 0.73 | KMT2A (0.38) | KMT2ALMNAMEN1ABCC4PKM | |
| SCHEMBL10278384 | 0.72 | LMNA (0.74) | KMT2ALMNAMEN1ABCC4PKM | |
| SCHEMBL9284683 | 0.69 | AXL (0.31) | LRRK2 | |
| SCHEMBL9284843 | 0.68 | MTNR1A (0.35) | KMT2AMEN1KDM4EMAPT | |
| SCHEMBL25898491 | 0.67 | KMT2A (0.38) | KMT2ALMNAMEN1ABCC4PKM | |
| SCHEMBL25889328 | 0.65 | KMT2A (0.36) | KMT2ALMNAMEN1ABCC4PKM | |
| SCHEMBL792371 | 0.63 | MEN1 (0.57) | KMT2ALMNAMEN1ABCC4PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103228656-B | 3-substituent-6- (pyridylmethoxy) -pyrrolopyridine compounds | ELI LILLY AND CO. (US) | 2015-09-30 | — | — | CN | disclosed |
| EP-2646437-B1 | 3-SUBSTITUTED-6-(PYRIDINYLMETHOXY)-PYRROLOPYRIDINE COMPOUNDS | LILLY CO ELI (US) | 2014-09-03 | — | — | EP | disclosed |
| EP-2646437-B1 | 3-SUBSTITUTED-6-(PYRIDINYLMETHOXY)-PYRROLOPYRIDINE COMPOUNDS | LILLY CO ELI (US) | 2014-09-03 | — | — | EP | disclosed |
| US-8778946-B2 | 3-substituted-6-(pyridinylmethoxy)-pyrrolopyridine compounds | ELI LILLY AND COMPANY (US) | 2014-07-15 | — | — | US | disclosed |
| US-8778946-B2 | 3-substituted-6-(pyridinylmethoxy)-pyrrolopyridine compounds | ELI LILLY AND COMPANY (US) | 2014-07-15 | — | — | US | disclosed |
| US-8778946-B2 | 3-substituted-6-(pyridinylmethoxy)-pyrrolopyridine compounds | ELI LILLY AND COMPANY (US) | 2014-07-15 | — | — | US | disclosed |
| EP-2646437-A1 | 3-SUBSTITUTED-6-(PYRIDINYLMETHOXY)-PYRROLOPYRIDINE COMPOUNDS | Eli Lilly and Company (US) | 2013-10-09 | — | — | EP | disclosed |
| US-20130225602-A1 | 3-SUBSTITUTED-6-(PYRIDINYLMETHOXY)-PYRROLOPYRIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2013-08-29 | — | — | US | disclosed |
| US-20130225602-A1 | 3-SUBSTITUTED-6-(PYRIDINYLMETHOXY)-PYRROLOPYRIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2013-08-29 | — | — | US | disclosed |
| US-20130225602-A1 | 3-SUBSTITUTED-6-(PYRIDINYLMETHOXY)-PYRROLOPYRIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2013-08-29 | — | — | US | disclosed |
| CN-103228656-A | 3-substituent-6- (pyridylmethoxy) -pyrrolopyridine compounds | LILLY CO ELI | 2013-07-31 | — | — | CN | disclosed |
| WO-2012074769-A1 | 3-SUBSTITUTED-6-(PYRIDINYLMETHOXY)-PYRROLOPYRIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2012-06-07 | — | — | WO | disclosed |
| WO-2012074769-A1 | 3-SUBSTITUTED-6-(PYRIDINYLMETHOXY)-PYRROLOPYRIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225602-A1 | 3-SUBSTITUTED-6-(PYRIDINYLMETHOXY)-PYRROLOPYRIDINE COMPOUNDS | PARK7, SNCA, PINK1 | KMT2A 3864/4885LMNA 3940/4885MEN1 2350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.