Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7344883 | 0.83 | EPHX2 (0.30) | — | |
| SCHEMBL1027767 | 0.71 | NPY5R (0.41) | — | |
| SCHEMBL18097052 | 0.67 | — | — | |
| SCHEMBL1026496 | 0.66 | HTR1A (0.48) | — | |
| SCHEMBL10617679 | 0.63 | KDM4E (0.36) | — | |
| SCHEMBL1789638 | 0.62 | TDP2 (0.45) | — | |
| SCHEMBL7001370 | 0.62 | AURKA (0.40) | PARP1AURKA | |
| SCHEMBL7342582 | 0.61 | CHRM3 (0.50) | — | |
| SCHEMBL1010887 | 0.60 | CTSD (0.31) | — | |
| SCHEMBL7347949 | 0.60 | DRD2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436240-A | Schizophrenia, Parkinson's disease, depression or hypotensive agents using tricyclic amines | THE UPJOHN COMPANY (US) | 1995-07-25 | — | — | US | disclosed |