Sugi Predict

Sugi Predict / Compounds / SCHEMBL9285186

SCHEMBL9285186

SCHEMBL9285186

Cc1ccc(S(=O)(=O)n2cc(/C=N/[S+]([O-])C(C)(C)C)cn2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GRM4 Q14833 2/20 0.39
▸ KMT2A Q03164 4/20 0.37
▸ MEN1 O00255 3/20 0.37
▸ ALDH1A1 P00352 7/20 0.35
▸ MAPT P10636 2/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ LMNA P02545 2/20 0.35
▸ CA1 P00915 2/20 0.33
▸ CA2 P00918 2/20 0.33
▸ HTT P42858 2/20 0.33
▸ USP2 O75604 1/20 0.33
▸ ALOX15 P16050 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ PIK3CD O00329 1/20 0.33
▸ PIK3CA P42336 1/20 0.33
▸ PIK3CB P42338 1/20 0.33
▸ PIK3CG P48736 1/20 0.33
▸ PKM P14618 2/20 0.33
▸ TSHR P16473 1/20 0.32
▸ TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19859821 1.00 GRM4 (0.39) GRM4KMT2AMEN1ALDH1A1MAPT
SCHEMBL3439396 1.00 GRM4 (0.39) GRM4KMT2AMEN1ALDH1A1MAPT
SCHEMBL23781233 0.78 ALDH1A1 (0.47) KMT2AMEN1ALDH1A1MAPTSMN1; SMN2
SCHEMBL23781231 0.78 ALDH1A1 (0.47) KMT2AMEN1ALDH1A1MAPTSMN1; SMN2
SCHEMBL23781232 0.78 ALDH1A1 (0.47) KMT2AMEN1ALDH1A1MAPTSMN1; SMN2
SCHEMBL568158 0.77 GRM4 (0.46) GRM4KMT2AMEN1ALDH1A1MAPT
SCHEMBL21047286 0.75 ALDH1A1 (0.41) KMT2AMEN1ALDH1A1MAPTCA1
SCHEMBL21047287 0.75 ALDH1A1 (0.41) KMT2AMEN1ALDH1A1MAPTCA1
SCHEMBL21047285 0.75 ALDH1A1 (0.41) KMT2AMEN1ALDH1A1MAPTCA1
SCHEMBL21047358 0.75 GAA (0.44) GRM4KMT2AMEN1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3497098-A1 FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME Zafgen, Inc. (US) 2019-06-19 — — EP disclosed
US-20190169181-A1 FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME ZAFGEN, INC. 2019-06-06 — — US disclosed
WO-2018031877-A1 FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME ZAFGEN, INC. (US) 2018-02-15 — — WO disclosed
US-8338610-B2 Pyridinyl compounds useful as intermediates BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-12-25 — — US disclosed
US-20120136158-A1 Pyridinyl Compounds Useful As Intermediates BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-05-31 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190169181-A1 FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME METAP2, DNPEP, FOLH1 GRM4 1644/4885KMT2A 1152/4885MEN1 446/4885
US-20120136158-A1 Pyridinyl Compounds Useful As Intermediates CCR1, CCRL2, CCR4 GRM4 1446/4885KMT2A 4793/4885MEN1 1895/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.