Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 18/20 | 0.41 |
| ▸ | GABRD | O14764 | 18/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 18/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 18/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 18/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 18/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 18/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 18/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 18/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 18/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 18/20 | 0.41 |
| ▸ | GABRE | P78334 | 18/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 18/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 18/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 18/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 18/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965183 | 0.70 | CDK4 (0.60) | CDK4CCND1CRHR1GABRPGABRD | |
| SCHEMBL7967756 | 0.70 | GABRP (0.61) | CDK4CCND1GABRPGABRDGABRA1 | |
| SCHEMBL6926985 | 0.67 | GABRP (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6923209 | 0.65 | GABRP (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7673341 | 0.64 | L3MBTL1 (0.34) | CDK4CCND1GABRPGABRDGABRA1 | |
| SCHEMBL9815197 | 0.63 | CDK4 (0.38) | CDK4CCND1GABRPGABRDGABRA1 | |
| SCHEMBL9768186 | 0.61 | GABRP (0.57) | CDK4CCND1GABRPGABRDGABRA1 | |
| SCHEMBL13696501 | 0.60 | HSD11B1 (0.37) | CDK4CCND1CRHR1 | |
| SCHEMBL27796545 | 0.60 | ALDH1A1 (0.52) | — | |
| SCHEMBL9662115 | 0.59 | GABRP (0.35) | CDK4CCND1CRHR1GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674642-A1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013677-A1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |