Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14145021 | 0.88 | CYP3A4 (0.50) | CYP3A4MAPTKDM4EIDO1THRB | |
| SCHEMBL125129 | 0.81 | CYP3A4 (0.52) | CYP3A4MAPTKDM4EIDO1THRB | |
| SCHEMBL2504732 | 0.81 | IDO1 (0.48) | CYP3A4MAPTKDM4EIDO1THRB | |
| SCHEMBL11526495 | 0.79 | RIPK1 (0.46) | CYP3A4MAPTKDM4EIDO1THRB | |
| Hydrochloric Acid SCHEMBL538794 | 0.79 | CYP3A4 (0.56) | CYP3A4MAPTKDM4EIDO1THRB | |
| Iodide SCHEMBL4994541 | 0.79 | CYP3A4 (0.50) | CYP3A4MAPTKDM4EIDO1THRB | |
| Water SCHEMBL13583453 | 0.79 | CYP3A4 (0.56) | CYP3A4MAPTKDM4EIDO1THRB | |
| Bromide SCHEMBL11038149 | 0.79 | CYP3A4 (0.50) | CYP3A4MAPTKDM4EIDO1THRB | |
| SCHEMBL5431000 | 0.77 | IDO1 (0.50) | CYP3A4MAPTKDM4EIDO1THRB | |
| SCHEMBL19963515 | 0.77 | CYP2D6 (0.48) | CYP3A4MAPTKDM4EIDO1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173660-B2 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. (NL) | 2012-05-08 | — | — | US | disclosed |
| US-20110003830-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND SOLVATES THEREOF | SOLVAY PHARMACEUTICALS B.V. (NL) | 2011-01-06 | — | — | US | disclosed |
| US-7776860-B2 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. (NL) | 2010-08-17 | — | — | US | disclosed |
| EP-1732556-B1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND HYDRATES THEREOF | SOLVAY PHARM BV (NL) | 2008-03-12 | — | — | EP | disclosed |
| EP-1732556-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND HYDRATES THEREOF | Solvay Pharmaceuticals B.V. (NL) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092338-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL) -2H-1-BENZOPYRAN-2-ONE AND SALTS AND HYDRATES THEREOF | SOLVAY PHARMACEUTICALS B.V. (NL) | 2005-10-06 | — | — | WO | disclosed |
| US-20050215566-A1 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215566-A1 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | HTR1D, HTR1A, HTR1E | CYP3A4 476/4885MAPT 3258/4885KDM4E 2865/4885 |
| US-20110003830-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND SOLVATES THEREOF | HTR1D, HTR1A, HTR1E | CYP3A4 476/4885MAPT 3258/4885KDM4E 2865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.