Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rezatomidine SCHEMBL7799658 | 0.77 | ADRA2A (0.53) | KDM4EGAAKMT2ATSHRALDH1A1 | |
| Rezatomidine SCHEMBL345466 | 0.77 | ADRA2A (0.53) | KDM4EGAAKMT2ATSHRALDH1A1 | |
| Rezatomidine SCHEMBL676215 | 0.77 | ADRA2A (0.53) | KDM4EGAAKMT2ATSHRALDH1A1 | |
| SCHEMBL18763821 | 0.75 | KDM4E (0.50) | KDM4EGAAKMT2AATMFFAR4 | |
| SCHEMBL27687124 | 0.72 | KDM4E (0.48) | KDM4EGAAKMT2AATMFFAR4 | |
| SCHEMBL29841597 | 0.72 | LMNA (0.47) | KDM4EGAAKMT2AATMFFAR4 | |
| SCHEMBL13366640 | 0.72 | KDM4E (0.50) | KDM4EGAAKMT2AATMFFAR4 | |
| SCHEMBL19611955 | 0.72 | LMNA (0.47) | KDM4EGAAKMT2AATMFFAR4 | |
| SCHEMBL9290481 | 0.71 | KDM4E (0.42) | NR4A2KDM4EGAAKMT2AATM | |
| SCHEMBL3511612 | 0.69 | LMNA (0.59) | NR4A2KDM4EKMT2AATMFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120136035-A1 | 4-(1-(3-(HYDROXYMETHYL)-2-METHYLPHENYL)ETHYL)-1H-IMIDAZOLE-2(3H)-THIONE | ALLERGAN, INC. (US) | 2012-05-31 | — | — | US | disclosed |
| WO-2010093910-A1 | 4-(1-(3-(HYDROXYMETHYL)-2-METHYLPHENYL)ETHYL)-1H-IMIDAZOLE-2(3H)-THIONE | ALLERGAN, INC. (US) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136035-A1 | 4-(1-(3-(HYDROXYMETHYL)-2-METHYLPHENYL)ETHYL)-1H-IMIDAZOLE-2(3H)-THIONE | OPRK1, OPRD1, TPMT | NR4A2 450/4885KDM4E 1708/4885GAA 3907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.