Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | ACR | P10323 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11298774 | 0.87 | MAPT (0.70) | ALDH1A1MAPTSMN1; SMN2LMNACYP1A2 | |
| SCHEMBL13038164 | 0.86 | MAPT (0.54) | ALDH1A1MAPTSMN1; SMN2LMNACYP1A2 | |
| SCHEMBL11416082 | 0.86 | MAPT (0.54) | ALDH1A1MAPTSMN1; SMN2LMNACYP1A2 | |
| SCHEMBL9291194 | 0.85 | KMT2A (0.53) | ALDH1A1MAPTSMN1; SMN2LMNACYP1A2 | |
| SCHEMBL9292259 | 0.83 | LMNA (0.57) | MAPTSMN1; SMN2LMNACYP1A2CYP2C9 | |
| SCHEMBL9292054 | 0.83 | LMNA (0.51) | MAPTSMN1; SMN2LMNACYP1A2CYP2C9 | |
| SCHEMBL4067375 | 0.83 | DRD2 (0.53) | ALDH1A1MAPTSMN1; SMN2KMT2ACA1 | |
| SCHEMBL11406218 | 0.82 | MAPT (0.54) | ALDH1A1MAPTSMN1; SMN2LMNACYP1A2 | |
| SCHEMBL9291727 | 0.82 | LMNA (0.60) | MAPTSMN1; SMN2LMNACYP1A2CYP2C9 | |
| SCHEMBL6882393 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MAPTSMN1; SMN2KMT2ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356563-A | Two plate electrooptical cell | HOFFMANN-LA ROCHE INC. (US) | 1994-10-18 | — | — | US | disclosed |
| US-5244597-A | Liquid crystalline mixtures having a chiral tilted smectic phase | HOFFMANN-LA ROCHE INC. (US) | 1993-09-14 | — | — | US | disclosed |
| EP-0343487-A1 | Cyclohexyl esters of alpha-fluoro/carboxylic acids | F. HOFFMANN-LA ROCHE AG (CH) | 1989-11-29 | — | — | EP | disclosed |