Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GNPAT | O15228 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11732508 | 0.78 | MAPT (0.57) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL3166192 | 0.78 | KDM4E (0.42) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL27610443 | 0.76 | KDM4E (0.61) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL11108850 | 0.74 | REN (0.40) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL11108853 | 0.74 | REN (0.40) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL2992278 | 0.73 | KDM4E (0.47) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL10609030 | 0.67 | NOD1 (0.43) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL13922716 | 0.67 | KDM4E (0.39) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL19479440 | 0.66 | HIF1A (0.42) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL14967166 | 0.66 | HIF1A (0.42) | MAPTKDM4ETHRBALOX15NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276140-A | Hydrazide, semicarbazide or thiosemicarbizide agents for linking aldehydes or sulfhydryl groups | CETUS ONCOLOGY CORPORATION (US) | 1994-01-04 | — | — | US | disclosed |
| US-5034514-A | Agents for crosslinking aldehyde groups to sulfhydryl groups in immunoglobulins | CETUS CORPORATION (US) | 1991-07-23 | — | — | US | disclosed |
| US-4797491-A | SPACERS; BIOCHEMICAL | CETUS CORPORATION (US) | 1989-01-10 | — | — | US | disclosed |
| EP-0240200-A2 | Cross-linking agents, their use and preparation | CETUS CORPORATION (US) | 1987-10-07 | — | — | EP | disclosed |