SCHEMBL92964

SCHEMBL92964

CN(C)c1ccc2c(-c3ccc(C(=O)O)cc3C(=O)O)c3ccc(=N)cc-3oc2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RY6 Q15077 1/20 0.49
ABCB1 P08183 1/20 0.48
USP2 O75604 3/20 0.46
CFTR P13569 1/20 0.46
PAX8 Q06710 1/20 0.46
ATM Q13315 1/20 0.46
GOPC Q9HD26 1/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
THRB P10828 1/20 0.46
RECQL P46063 1/20 0.46
BLM P54132 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.44
CA9 Q16790 5/20 0.42
CA1 P00915 4/20 0.42
CA2 P00918 4/20 0.42
CA12 O43570 3/20 0.42
SLC16A3 O15427 1/20 0.40
GBA1 P04062 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14942851 0.90 ABCB1 (0.48) P2RY6ABCB1USP2CFTRPAX8
SCHEMBL7970138 0.88 USP2 (0.57) P2RY6USP2ATMMEN1KMT2A
SCHEMBL13848619 0.88 ABCB1 (0.58) P2RY6ABCB1USP2CFTRPAX8
SCHEMBL13066053 0.88 P2RY6 (0.53) P2RY6ABCB1USP2CFTRPAX8
SCHEMBL13805717 0.88 MEN1 (0.46) P2RY6ABCB1USP2CFTRPAX8
SCHEMBL10293759 0.87 P2RY6 (0.64) P2RY6ABCB1USP2MEN1KMT2A
SCHEMBL13078711 0.86 ABCB1 (0.49) P2RY6ABCB1USP2CFTRPAX8
SCHEMBL7006557 0.86 ABCB1 (0.50) P2RY6ABCB1USP2CFTRPAX8
SCHEMBL14415041 0.86 P2RY6 (0.48) P2RY6ABCB1USP2MEN1KMT2A
SCHEMBL17777839 0.86 P2RY6 (0.48) P2RY6ABCB1USP2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8129529-B2 UV excitable fluorescent energy transfer dyes APPLIED BIOSYSTEMS, LLC (US) 2012-03-06 US disclosed
US-7888507-B2 UV excitable fluorescent energy transfer dyes APPLIED BIOSYSTEMS, LLC 2011-02-15 US disclosed
US-20100280246-A1 ENERGY TRANSFER DYES WITH ENHANCED FLUORESCENCE APPLERA CORPORATION (US) 2010-11-04 US disclosed
US-7595162-B2 Methods of labeling polynucleotides with energy transfer dyes APPLIED BIOSYSTEMS, LLC (US) 2009-09-29 US disclosed
US-20090118485-A1 OLIGONUCLEOTIDES AND ANALOGS LABELED WITH ENERGY TRANSFER DYES APPLIED BIOSYSTEMS INC. (US) 2009-05-07 US disclosed
EP-1212457-B1 UV EXCITABLE FLUORESCENT ENERGY TRANSFER DYES APPLIED BIOSYSTEMS LLC (US) 2009-05-06 EP disclosed
US-20090031506-A1 UV Excitable Fluorescent Energy Transfer Dyes APPLERA CORPORATION (US) 2009-02-05 US disclosed
US-20080268509-A1 METHODS OF LABELING POLYNUCLEOTIDES WITH ENERGY TRANSFER DYES APPLERA CORPORATION (US) 2008-10-30 US disclosed
US-7432058-B2 Methods of labeling nucleic acids with energy transfer dyes APPLERA CORPORATION (US) 2008-10-07 US disclosed
US-7402671-B2 UV excitable fluorescent energy transfer dyes APPLERA CORPORATION (US) 2008-07-22 US disclosed
US-7399854-B2 Regents labeled with energy transfer dyes APPLERA CORPORATION (US) 2008-07-15 US disclosed
US-7388092-B2 Oligonucleotides and analogs labeled with energy transfer dyes APPLERA CORPORATION (US) 2008-06-17 US disclosed
US-20070161026-A1 REGENTS LABELED WITH ENERGY TRANSFER DYES APPLERA CORPORATION (US) 2007-07-12 US disclosed
US-20070161027-A1 OLIGONUCLEOTIDES AND ANALOGS LABELED WITH ENERGY TRANSFER DYES APPLERA CORPORATION (US) 2007-07-12 US disclosed
US-20070154927-A1 ENERGY TRANSFER DYES WITH ENHANCED FLUORESCENCE APPLERA CORPORATION (US) 2007-07-05 US disclosed
US-7169939-B2 Energy transfer dyes with enhanced fluorescence APPLERA CORPORATION (US) 2007-01-30 US disclosed
US-7157572-B2 UV excitable energy transfer reagents APPLERA CORPORATION (US) 2007-01-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100280246-A1 ENERGY TRANSFER DYES WITH ENHANCED FLUORESCENCE SLC25A21, ZCCHC8, ZDHHC7 P2RY6 4446/4885ABCB1 3271/4885USP2 4500/4885
US-20070161027-A1 OLIGONUCLEOTIDES AND ANALOGS LABELED WITH ENERGY TRANSFER DYES RBM28, TRDMT1, RTCB P2RY6 4273/4885ABCB1 3036/4885USP2 4741/4885
US-20070161026-A1 REGENTS LABELED WITH ENERGY TRANSFER DYES SOAT1, GFPT1, CBR3 P2RY6 4094/4885ABCB1 3463/4885USP2 4361/4885
US-20090118485-A1 OLIGONUCLEOTIDES AND ANALOGS LABELED WITH ENERGY TRANSFER DYES RBM28, TRDMT1, RTCB P2RY6 4273/4885ABCB1 3036/4885USP2 4741/4885
US-20070154927-A1 ENERGY TRANSFER DYES WITH ENHANCED FLUORESCENCE SLC25A21, ZCCHC8, SLC25A1 P2RY6 4355/4885ABCB1 3109/4885USP2 4576/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.