Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.38 |
| ▸ | JAK1 | P23458 | 10/20 | 0.38 |
| ▸ | TYK2 | P29597 | 10/20 | 0.38 |
| ▸ | JAK3 | P52333 | 10/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9298907 | 0.84 | KDM4E (0.37) | TGFBR1 | |
| SCHEMBL8977924 | 0.76 | RAB9A (0.45) | — | |
| Sulfuric Acid SCHEMBL5497691 | 0.70 | SMPD3 (0.33) | — | |
| SCHEMBL5204576 | 0.67 | TSHR (0.44) | RIPK2TLR8 | |
| SCHEMBL6397435 | 0.66 | SMN1; SMN2 (0.49) | RIPK2TLR8 | |
| SCHEMBL174225 | 0.66 | RIPK2 (0.51) | TYK2RIPK2TLR8 | |
| SCHEMBL20594722 | 0.66 | L3MBTL1 (0.36) | IRAK4 | |
| SCHEMBL9923339 | 0.66 | JAK2 (0.58) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL13355648 | 0.65 | TGFBR1 (0.57) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL21083418 | 0.65 | EPHB3 (0.55) | JAK2JAK1TYK2JAK3TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5302712-A | Intermediates for cephem compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-12 | — | — | US | disclosed |
| US-5215982-A | Antibiotics | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-01 | — | — | US | disclosed |
| EP-0427248-A2 | New cephem compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-15 | — | — | EP | disclosed |