SCHEMBL9300892

SCHEMBL9300892

CCCCc1nc(Cl)c(CO[Si](C)(C)C(C)(C)C)n1Cc1ccc(-c2ccccc2C(=O)NN)cc1

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 2/20 0.62
AGTR1 P30556 2/20 0.62
MME P08473 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9301140 0.92 AGTR2 (0.62) AGTR2AGTR1
SCHEMBL9293863 0.86 AGTR2 (0.82) AGTR2AGTR1
SCHEMBL9587419 0.82 AGTR1 (0.56) AGTR2AGTR1
SCHEMBL9586641 0.81 AGTR1 (0.51) AGTR2AGTR1
SCHEMBL9533206 0.81 AGTR1 (0.55) AGTR2AGTR1
SCHEMBL883 0.80 AGTR1 (0.69) AGTR2AGTR1
SCHEMBL760 0.80 AGTR2 (0.78) AGTR2AGTR1
SCHEMBL513 0.79 AGTR1 (0.82) AGTR2AGTR1
SCHEMBL9534120 0.79 AGTR1 (0.57) AGTR2AGTR1
SCHEMBL734 0.78 AGTR2 (0.69) AGTR2AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5338737-A Biphenyl oxadiazoles and thiadiazoles as angiotensin II antagonists WARNER-LAMBERT COMPANY (US) 1994-08-16 US disclosed
US-5210204-A Hypotensive agents and cardiovascular disorders WARNER-LAMBERT COMPANY (US) 1993-05-11 US disclosed