SCHEMBL9301140

SCHEMBL9301140

CCCCc1nc(Cl)c(CO[Si](C)(C)C(C)(C)C)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 2/20 0.62
AGTR1 P30556 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9300892 0.92 AGTR2 (0.62) AGTR2AGTR1
SCHEMBL883 0.89 AGTR1 (0.69) AGTR2AGTR1
SCHEMBL462 0.87 AGTR2 (0.80) AGTR2AGTR1
SCHEMBL8792660 0.86 AGTR2 (0.70) AGTR2AGTR1
SCHEMBL9533206 0.86 AGTR1 (0.55) AGTR2AGTR1
Hydrochloric Acid SCHEMBL484 0.85 AGTR2 (0.69) AGTR2AGTR1
SCHEMBL734 0.85 AGTR2 (0.69) AGTR2AGTR1
SCHEMBL8790075 0.85 AGTR2 (0.64) AGTR2AGTR1
SCHEMBL8792554 0.84 AGTR2 (0.63) AGTR2AGTR1
SCHEMBL714 0.84 SLC6A4 (0.43) AGTR2AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5338737-A Biphenyl oxadiazoles and thiadiazoles as angiotensin II antagonists WARNER-LAMBERT COMPANY (US) 1994-08-16 US disclosed
US-5210204-A Hypotensive agents and cardiovascular disorders WARNER-LAMBERT COMPANY (US) 1993-05-11 US disclosed