SCHEMBL9533206

SCHEMBL9533206

CCCCc1nc(Cl)c(CO[Si](C)(C)C(C)(C)C)n1Cc1ccc(C(=O)OC)cc1

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 1/20 0.55
AGTR2 P50052 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9587419 0.88 AGTR1 (0.56) AGTR1AGTR2
SCHEMBL9586641 0.87 AGTR1 (0.51) AGTR1AGTR2
SCHEMBL556 0.87 AGTR1 (0.62) AGTR1AGTR2
SCHEMBL9585230 0.87 TLR7 (0.49) AGTR1AGTR2
SCHEMBL9301140 0.86 AGTR2 (0.62) AGTR1AGTR2
SCHEMBL8793373 0.84 AGTR1 (0.63) AGTR1AGTR2
SCHEMBL9534120 0.81 AGTR1 (0.57) AGTR1AGTR2
SCHEMBL9300892 0.81 AGTR2 (0.62) AGTR1AGTR2
SCHEMBL9586364 0.80 AGTR1 (0.50) AGTR1AGTR2
SCHEMBL8792643 0.79 AGTR1 (0.54) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0515548-A4 IMIDAZOLE ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT 1993-03-10 EP disclosed
US-5183810-A Hyptoensive agents MERCK & CO., INC. (US) 1993-02-02 US disclosed
EP-0515548-A1 IMIDAZOLE ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT MERCK & CO. INC. (US) 1992-12-02 EP disclosed
WO-1991012002-A1 IMIDAZOLE ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT MERCK & CO., INC. (US) 1991-08-22 WO disclosed