SCHEMBL9300925

SCHEMBL9300925

CC(=O)N1C(C)(C)CC(NC(=O)NN)CC1(C)C

nearest known ligand 0.37

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 14/20 0.37
EPHX1 P07099 2/20 0.34
KDM4E B2RXH2 2/20 0.33
GAA P10253 2/20 0.33
KMT2A Q03164 1/20 0.31
ESR1 P03372 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8337045 0.85 GAA (0.33) EPHX2KDM4EGAAKMT2A
SCHEMBL8336929 0.82 HDAC4 (0.36) EPHX2EPHX1KDM4EGAAKMT2A
SCHEMBL9008680 0.76 KDM4E (0.33) EPHX2KDM4EGAAKMT2AESR1
SCHEMBL12863508 0.75 TEAD1 (0.34) EPHX2KDM4EGAAKMT2A
SCHEMBL9002566 0.75 KDM4E (0.33) EPHX2KDM4EGAAKMT2A
SCHEMBL9152918 0.73 EPHX1 (0.40) EPHX2EPHX1KDM4EGAAKMT2A
SCHEMBL9154182 0.73 MAPT (0.33) KDM4EGAAKMT2AESR1
SCHEMBL9299461 0.73 POLB (0.35) KDM4E
SCHEMBL8335952 0.73 RECQL (0.50) KDM4EGAAKMT2A
SCHEMBL4351927 0.72 L3MBTL1 (0.46) EPHX2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9238609-B2 Dicarboxylic acid monomers and methods of making and using the same SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2016-01-19 US disclosed
US-20150336869-A1 DICARBOXYLIC ACID MONOMERS AND METHODS OF MAKING AND USING THE SAME SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-26 US disclosed
WO-2015171709-A1 AMORPHOUS POLYESTER COMPOSITIONS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-12 WO disclosed
US-20150322200-A1 AMORPHOUS POLYESTER COMPOSITIONS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-12 US disclosed
US-8633265-B2 UV stabilization of isosorbide polycarbonates SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2014-01-21 US disclosed
EP-2665775-A1 UV STABILIZATION OF ISOSORBIDE POLYCARBONATES SABIC Innovative Plastics IP B.V. (NL) 2013-11-27 EP disclosed
WO-2012098513-A1 UV STABILIZATION OF ISOSORBIDE POLYCARBONATES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-07-26 WO disclosed
US-20120184651-A1 UV Stabilization of Isosorbide Polycarbonates SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2012-07-19 US disclosed
US-RE34791-E Polymer bound hindered amine light stabilizers ATOCHEM NORTH AMERICA, INC. (US) 1994-11-15 US disclosed
EP-0303987-B1 POLYMER BOUND HINDERED AMINE LIGHT STABILIZERS ATOCHEM NORTH AMERICA, INC. (US) 1992-10-14 EP disclosed
US-4978699-A Reaction product of hindered amine with primary amine or reactive hydrazide group and halogenated cyclic anhydride; for extrusion with polymers ATOCHEM NORTH AMERICA, INC. (US) 1990-12-18 US disclosed
US-4975489-A Heating an anhydride-containing polymer with a hydrazine derivative of a 2,2,6,6-tetramethyl-4-aminopiperidine in an inert solvent of by melt blending ATOCHEM NORTH AMERICA, INC. (US) 1990-12-04 US disclosed
EP-0366057-A2 Light stabilizing flame retardants ATOCHEM NORTH AMERICA, INC. (a Pennsylvania corp.) (US) 1990-05-02 EP disclosed
US-4857595-A Polymer bound hindered amine light stabilizers PENNWALT CORPORATION (US) 1989-08-15 US disclosed
US-4824884-A Cyclic anhydride derivatives of hydrazide functionalized hindered amine light stabilizers PENNWALT CORPORATION (US) 1989-04-25 US disclosed
EP-0303282-A2 Cyclic anhydride derivatives of hydrazide functionalized hindered amine light stabilizers ATOCHEM NORTH AMERICA, INC. (US) 1989-02-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150336869-A1 DICARBOXYLIC ACID MONOMERS AND METHODS OF MAKING AND USING THE SAME PGD, CDA, PPIA EPHX2 2180/4885EPHX1 3944/4885KDM4E 4025/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.