Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.52 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ITGAV | P06756 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9176062 | 0.86 | LMNA (0.57) | LMNAALKBH2ALKBH3CA1CA2 | |
| SCHEMBL3637063 | 0.84 | LMNA (0.68) | LMNAALKBH2ALKBH3CA1CA2 | |
| SCHEMBL28684587 | 0.83 | LMNA (0.54) | LMNAALKBH2ALKBH3CA1CA2 | |
| SCHEMBL8650243 | 0.81 | KAT6A (0.56) | LMNAALKBH2ALKBH3MEN1KMT2A | |
| SCHEMBL28933292 | 0.80 | LMNA (0.54) | LMNAALKBH2ALKBH3CA1CA2 | |
| SCHEMBL6159257 | 0.80 | MEN1 (0.69) | LMNAMEN1KMT2AKAT6APBRM1 | |
| SCHEMBL9303677 | 0.79 | SMN1; SMN2 (0.60) | LMNAMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL6641114 | 0.79 | KMT2A (0.60) | LMNAALKBH2ALKBH3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8303230 | 0.78 | MEN1 (0.68) | LMNAMEN1KMT2AKAT6APBRM1 | |
| SCHEMBL9178001 | 0.78 | CA1 (0.58) | LMNAALKBH2ALKBH3CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360802-A | Antagonists of cholecystokinin and gastrin | MERCK SHARPE & DOHME LTD. | 1994-11-01 | — | — | US | disclosed |
| EP-0514133-A1 | Benzodiazepine derivatives, compositions containing them and their use in therapy | MERCK SHARP & DOHME LTD. (GB) | 1992-11-19 | — | — | EP | disclosed |