Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9176062 | 0.83 | LMNA (0.57) | KAT6ARAB9ANPC1MEN1KMT2A | |
| SCHEMBL3637063 | 0.81 | LMNA (0.68) | KAT6AMEN1KMT2ALMNAALKBH2 | |
| SCHEMBL9301023 | 0.81 | LMNA (0.54) | KAT6ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28684587 | 0.81 | LMNA (0.54) | KAT6ARAB9ANPC1MEN1KMT2A | |
| SCHEMBL28933292 | 0.81 | LMNA (0.54) | KAT6ALMNAALKBH2ALKBH3 | |
| SCHEMBL10772949 | 0.79 | ALKBH2 (0.43) | KAT6ALMNAALKBH2ALKBH3 | |
| SCHEMBL2172190 | 0.79 | NPC1 (0.62) | KAT6ARAB9ANPC1MEN1KMT2A | |
| SCHEMBL31516646 | 0.78 | KAT6A (0.55) | KAT6ARAB9ANPC1MEN1KMT2A | |
| SCHEMBL9303677 | 0.77 | SMN1; SMN2 (0.60) | MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL7986975 | 0.76 | NPC1 (0.59) | KAT6ARAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863873-A1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER INC. (US) | 1998-09-16 | — | — | EP | claimed |
| WO-1997013751-A1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER INC. (US) | 1997-04-17 | — | — | WO | claimed |
| CN-114059090-A | Preparation method of benzo [ e ] [1,4,3] oxathiazine-1, 1-dioxide derivative | 福州大学 | 2022-02-18 | — | — | CN | disclosed |
| EP-0748312-A1 | BICYCLIC CARBAMATES AS LEUKOTRIENE D4 ANTAGONISTS | PFIZER INC. (US) | 1996-12-18 | — | — | EP | disclosed |
| WO-1995023789-A1 | BICYCLIC CARBAMATES AS LEUKOTRIENE D4 ANTAGONISTS | PFIZER INC. (US) | 1995-09-08 | — | — | WO | disclosed |
| US-5439929-A | Antagonist of leukotriene D4; blocking the leukotriene D4 receptor | PFIZER INC. (US) | 1995-08-08 | — | — | US | disclosed |