Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10379764 | 0.87 | L3MBTL1 (0.62) | MEN1KMT2AKCNH2ABCB1MAPT | |
| SCHEMBL9300786 | 0.87 | MAPT (0.48) | MEN1KMT2ALMNASMN1; SMN2ABCB1 | |
| SCHEMBL9300738 | 0.85 | HTR7 (0.50) | MEN1KMT2ALMNASMN1; SMN2ABCB1 | |
| SCHEMBL9193205 | 0.85 | L3MBTL1 (0.59) | MEN1KMT2AKCNH2ABCB1MAPT | |
| SCHEMBL9187274 | 0.85 | MAPT (0.60) | MEN1KMT2AKCNH2ABCB1MAPT | |
| SCHEMBL8617368 | 0.83 | KCNH2 (0.52) | MEN1KMT2AKCNH2LMNASMN1; SMN2 | |
| SCHEMBL9141618 | 0.83 | MAPT (0.49) | MEN1KMT2AKCNH2LMNASMN1; SMN2 | |
| SCHEMBL9300891 | 0.82 | TSHR (0.64) | MEN1KMT2AKCNH2LMNASMN1; SMN2 | |
| SCHEMBL9301602 | 0.82 | TSHR (0.64) | MEN1KMT2AKCNH2LMNASMN1; SMN2 | |
| SCHEMBL9301397 | 0.82 | MAPT (0.57) | MEN1KMT2AATMKCNH2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5342839-A | Useful for therapy of oxygen deficiency diseases of the brain | BASF AKTIENGESELLSCHAFT (DE) | 1994-08-30 | — | — | US | disclosed |
| WO-1990003371-A1 | 2-HYDROXY-3-PHENOXY-PROPYL-SUBSTITUTED PIPERAZINES AND HOMOPIPERAZINES, THEIR MANUFACTURE AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1990-04-05 | — | — | WO | disclosed |