Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD5 | P21918 | 2/20 | 0.47 |
| ▸ | HRH2 | P25021 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | HTR5A | P47898 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301048 | 0.85 | MEN1 (0.53) | ADRA1ADRD3ABCB1MEN1KMT2A | |
| SCHEMBL10379764 | 0.84 | L3MBTL1 (0.62) | ABCB1MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL9300786 | 0.82 | MAPT (0.48) | HTR7SLC6A3CACNA1FDRD1DRD4 | |
| SCHEMBL9193205 | 0.82 | L3MBTL1 (0.59) | ABCB1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9187274 | 0.82 | MAPT (0.60) | ABCB1MEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL9301397 | 0.79 | MAPT (0.57) | ABCB1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL14417535 | 0.78 | HTR1A (0.60) | HTR7HTR1AABCB1MEN1KMT2A | |
| SCHEMBL9271436 | 0.78 | CACNA1G (0.67) | MEN1KMT2AMAPT | |
| SCHEMBL9300891 | 0.78 | TSHR (0.64) | HTR7SLC6A3CACNA1FDRD1DRD5 | |
| SCHEMBL9301602 | 0.78 | TSHR (0.64) | HTR7SLC6A3CACNA1FDRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5342839-A | Useful for therapy of oxygen deficiency diseases of the brain | BASF AKTIENGESELLSCHAFT (DE) | 1994-08-30 | — | — | US | disclosed |
| WO-1990003371-A1 | 2-HYDROXY-3-PHENOXY-PROPYL-SUBSTITUTED PIPERAZINES AND HOMOPIPERAZINES, THEIR MANUFACTURE AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1990-04-05 | — | — | WO | disclosed |