Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | USP2 | O75604 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300891 | 1.00 | TSHR (0.64) | TSHRUSP2MAPTKDM4EGLA | |
| SCHEMBL9187274 | 0.94 | MAPT (0.60) | TSHRUSP2MAPTKDM4EGLA | |
| SCHEMBL9301397 | 0.91 | MAPT (0.57) | TSHRMAPTKDM4EGLAMEN1 | |
| SCHEMBL10379764 | 0.90 | L3MBTL1 (0.62) | TSHRMAPTKDM4EMEN1KMT2A | |
| SCHEMBL9193205 | 0.90 | L3MBTL1 (0.59) | TSHRMAPTKDM4EGLAMEN1 | |
| SCHEMBL9271436 | 0.89 | CACNA1G (0.67) | TSHRMAPTKDM4EGLAMEN1 | |
| SCHEMBL9301630 | 0.89 | MAPT (0.55) | TSHRUSP2MAPTKDM4EGLA | |
| SCHEMBL9301222 | 0.88 | MAPT (0.53) | TSHRMAPTKDM4EGLAMEN1 | |
| SCHEMBL9301158 | 0.88 | CACNA1G (0.67) | TSHRMAPTKDM4EGLAMEN1 | |
| SCHEMBL9300427 | 0.85 | LMNA (0.59) | TSHRMAPTKDM4EGLAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5342839-A | Useful for therapy of oxygen deficiency diseases of the brain | BASF AKTIENGESELLSCHAFT (DE) | 1994-08-30 | — | — | US | disclosed |
| WO-1990003371-A1 | 2-HYDROXY-3-PHENOXY-PROPYL-SUBSTITUTED PIPERAZINES AND HOMOPIPERAZINES, THEIR MANUFACTURE AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1990-04-05 | — | — | WO | disclosed |