Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 7/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SCN1A | P35498 | 2/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9187274 | 0.93 | MAPT (0.60) | CACNA1GKCNH2MAPTTSHRMEN1 | |
| SCHEMBL9301397 | 0.89 | MAPT (0.57) | CACNA1GCYP2D6KCNH2MAPTTSHR | |
| SCHEMBL9301814 | 0.88 | CYP2D6 (0.54) | CACNA1GCYP2D6KCNH2MAPTSCN1A | |
| SCHEMBL9193205 | 0.88 | L3MBTL1 (0.59) | CACNA1GCYP2D6KCNH2MAPTTSHR | |
| SCHEMBL10379764 | 0.88 | L3MBTL1 (0.62) | CACNA1GCYP2D6KCNH2MAPTTSHR | |
| SCHEMBL9301602 | 0.88 | TSHR (0.64) | CACNA1GCYP2D6KCNH2MAPTTSHR | |
| SCHEMBL9300891 | 0.88 | TSHR (0.64) | CACNA1GCYP2D6KCNH2MAPTTSHR | |
| SCHEMBL9271436 | 0.88 | CACNA1G (0.67) | CACNA1GKCNH2MAPTTSHRMEN1 | |
| SCHEMBL9301487 | 0.87 | CYP2D6 (0.55) | CACNA1GCYP2D6KCNH2MAPTSCN1A | |
| SCHEMBL9301847 | 0.86 | CACNA1G (0.64) | CACNA1GCYP2D6KCNH2SCN1ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5342839-A | Useful for therapy of oxygen deficiency diseases of the brain | BASF AKTIENGESELLSCHAFT (DE) | 1994-08-30 | — | — | US | disclosed |
| WO-1990003371-A1 | 2-HYDROXY-3-PHENOXY-PROPYL-SUBSTITUTED PIPERAZINES AND HOMOPIPERAZINES, THEIR MANUFACTURE AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1990-04-05 | — | — | WO | disclosed |