Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 6/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | SCN1A | P35498 | 2/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300427 | 0.90 | LMNA (0.59) | TDP1LMNAALDH1A1MAPTHTT | |
| SCHEMBL9301158 | 0.87 | CACNA1G (0.67) | CYP2D6MAPTCACNA1GSCN1ASCN5A | |
| SCHEMBL9301847 | 0.81 | CACNA1G (0.64) | CYP2D6CACNA1GSCN1ASCN5ASCN9A | |
| SCHEMBL9301208 | 0.81 | CYP2D6 (0.61) | CYP2D6LMNAMAPTCACNA1GSCN1A | |
| SCHEMBL9187274 | 0.79 | MAPT (0.60) | ALDH1A1MAPTCACNA1GKCNH2KDM4E | |
| SCHEMBL9302021 | 0.79 | CYP2D6 (0.58) | CYP2D6MAPTCACNA1GSCN1ASCN5A | |
| SCHEMBL9192429 | 0.77 | KCNH2 (0.64) | LMNAALDH1A1MAPTDRD4CACNA1G | |
| SCHEMBL9301397 | 0.76 | MAPT (0.57) | CYP2D6ALDH1A1MAPTCACNA1GKCNH2 | |
| SCHEMBL9301814 | 0.76 | CYP2D6 (0.54) | CYP2D6LMNAMAPTCACNA1GSCN1A | |
| SCHEMBL9303300 | 0.76 | L3MBTL1 (0.70) | CYP2D6LMNAALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5342839-A | Useful for therapy of oxygen deficiency diseases of the brain | BASF AKTIENGESELLSCHAFT (DE) | 1994-08-30 | — | — | US | disclosed |
| EP-0435902-A1 | 2-HYDROXY-3-PHENOXY-PROPYL-SUBSTITUTED PIPERAZINES AND HOMOPIPERAZINES, THEIR MANUFACTURE AND USE. | BASF AG (DE) | 1991-07-10 | — | — | EP | disclosed |
| WO-1990003371-A1 | 2-HYDROXY-3-PHENOXY-PROPYL-SUBSTITUTED PIPERAZINES AND HOMOPIPERAZINES, THEIR MANUFACTURE AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1990-04-05 | — | — | WO | disclosed |