Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | CENPE | Q02224 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MDM4 | O15151 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7878088 | 0.78 | TSHR (0.66) | ELANEPKMALDH1A1KMT2AKDM4E | |
| SCHEMBL30639225 | 0.78 | TSHR (0.66) | ELANEPKMALDH1A1KMT2AKDM4E | |
| SCHEMBL8989478 | 0.78 | CENPE (0.53) | PKMALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9867870 | 0.77 | ALDH1A1 (0.68) | ELANEPKMALDH1A1KMT2AKDM4E | |
| SCHEMBL7843260 | 0.76 | GABRA2 (0.41) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL23931478 | 0.76 | ALDH1A1 (0.56) | ELANEPKMALDH1A1KMT2AKDM4E | |
| SCHEMBL8689676 | 0.76 | ALDH1A1 (0.56) | ELANEPKMALDH1A1KMT2AKDM4E | |
| SCHEMBL1920160 | 0.76 | MAPT (0.62) | ELANEPKMALDH1A1KMT2AKDM4E | |
| SCHEMBL7852329 | 0.75 | TP53 (0.41) | PKMALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL5172816 | 0.75 | KMT2A (0.48) | PKMALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354772-A | Anticholesterol agents | SANDOZ PHARM. CORP. (US) | 1994-10-11 | — | — | US | disclosed |
| US-4739073-A | ANTICHOLESTEROL AGENTS | SANDOZ PHARMACEUTICALS CORP. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0114027-B1 | ANALOGS OF MEVALOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS PHARMACEUTICALS | SANDOZ AG (CH) | 1988-01-07 | — | — | EP | disclosed |
| WO-1984002131-A1 | ANALOGS OF MEVALOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS PHARMACEUTICALS | SANDOZ AG (CH) | 1984-06-07 | — | — | WO | disclosed |