Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9302319 | 0.80 | KMT2A (0.54) | TDP1KMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL17175750 | 0.75 | ATM (0.66) | ATMTDP1L3MBTL1KMT2AMEN1 | |
| SCHEMBL9300858 | 0.72 | KDM4E (0.72) | ATMTDP1L3MBTL1KMT2AMEN1 | |
| SCHEMBL1945491 | 0.72 | KDM4E (0.66) | PSMD14KMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL6348563 | 0.69 | ALDH1A1 (0.62) | ATMKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6350010 | 0.69 | ALDH1A1 (1.00) | ATML3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1946617 | 0.67 | HPGD (0.59) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9300715 | 0.65 | L3MBTL1 (0.32) | TDP1L3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL9303416 | 0.64 | KDM4E (0.72) | ATML3MBTL1KMT2AMEN1 | |
| SCHEMBL18207662 | 0.64 | MEN1 (0.55) | KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314890-A | Treatment of asthma | MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A. (IT) | 1994-05-24 | — | — | US | disclosed |
| EP-0531349-A1 | 1-7 SUBSTITUTED XANTHINE DERIVATIVES HAVING ANTIASTHMATIC ACTIVITY, THEIR SALTS PHYSIOLOGICALLY ACCEPTABLE, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | MALESCI ISTITUTO FARMACOBIOLOGICO S.p.A. (IT) | 1993-03-17 | — | — | EP | disclosed |
| WO-1991017993-A1 | 1-7 SUBSTITUTED XANTHINE DERIVATIVES HAVING ANTIASTHMATIC ACTIVITY, THEIR SALTS PHYSIOLOGICALLY ACCEPTABLE, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A (IT) | 1991-11-28 | — | — | WO | disclosed |