SCHEMBL9302319

SCHEMBL9302319

CC(C)CN(C=O)c1c(N)n(Cc2ccccc2)c(=O)n(C)c1=O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.54
ALDH1A1 P00352 4/20 0.53
SMN1; SMN2 Q16637 4/20 0.53
LMNA P02545 3/20 0.53
MEN1 O00255 4/20 0.49
PKM P14618 3/20 0.49
HTT P42858 2/20 0.49
RAB9A P51151 1/20 0.47
GAA P10253 4/20 0.45
CYP2D6 P10635 2/20 0.45
CYP2C19 P33261 2/20 0.45
TSHR P16473 2/20 0.45
HPGD P15428 2/20 0.45
CYP3A4 P08684 1/20 0.45
USP2 O75604 1/20 0.44
MAPT P10636 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
KDM4E B2RXH2 1/20 0.43
CRHBP P24387 1/20 0.43
CRHR2 Q13324 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9301449 0.80 ATM (0.58) KMT2ASMN1; SMN2MEN1HTTTDP1
SCHEMBL7426213 0.74 ALDH1A1 (0.64) KMT2AALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL9305429 0.71 ADORA3 (0.44) KMT2AALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL3940708 0.70 HPGD (0.64) KMT2AALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL9300715 0.67 L3MBTL1 (0.32) KMT2AALDH1A1SMN1; SMN2GAAMAPT
SCHEMBL14016195 0.65 ALDH1A1 (0.53) KMT2AALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL9493903 0.65 ALDH1A1 (0.44) KMT2AALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL10769766 0.63 ALDH1A1 (0.50) KMT2AALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL23974605 0.63 HPGD (0.57) ALDH1A1SMN1; SMN2LMNAHTTTSHR
SCHEMBL29142975 0.63 CYP3A4 (1.00) KMT2AALDH1A1SMN1; SMN2LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5314890-A Treatment of asthma MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A. (IT) 1994-05-24 US disclosed
EP-0531349-A1 1-7 SUBSTITUTED XANTHINE DERIVATIVES HAVING ANTIASTHMATIC ACTIVITY, THEIR SALTS PHYSIOLOGICALLY ACCEPTABLE, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION MALESCI ISTITUTO FARMACOBIOLOGICO S.p.A. (IT) 1993-03-17 EP disclosed
WO-1991017993-A1 1-7 SUBSTITUTED XANTHINE DERIVATIVES HAVING ANTIASTHMATIC ACTIVITY, THEIR SALTS PHYSIOLOGICALLY ACCEPTABLE, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A (IT) 1991-11-28 WO disclosed