Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 9/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ATF4 | P18848 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300865 | 0.91 | KDM4E (0.53) | CACNA1GKCNH2MAPTHRH1ALDH1A1 | |
| SCHEMBL9187274 | 0.90 | MAPT (0.60) | CACNA1GKCNH2MAPTTSHRALDH1A1 | |
| SCHEMBL9301847 | 0.89 | CACNA1G (0.64) | CACNA1GKCNH2ATF4KMT2A | |
| SCHEMBL9271436 | 0.89 | CACNA1G (0.67) | CACNA1GKCNH2MAPTTSHRMEN1 | |
| SCHEMBL9189672 | 0.87 | CACNA1G (0.60) | CACNA1GKCNH2MAPTMEN1KMT2A | |
| SCHEMBL9301397 | 0.86 | MAPT (0.57) | CACNA1GKCNH2MAPTTSHRALDH1A1 | |
| SCHEMBL9301630 | 0.86 | MAPT (0.55) | CACNA1GKCNH2MAPTTSHRDRD2 | |
| SCHEMBL10379764 | 0.85 | L3MBTL1 (0.62) | CACNA1GKCNH2MAPTTSHRALDH1A1 | |
| SCHEMBL9193205 | 0.85 | L3MBTL1 (0.59) | CACNA1GKCNH2MAPTTSHRALDH1A1 | |
| SCHEMBL9300891 | 0.85 | TSHR (0.64) | CACNA1GKCNH2MAPTTSHRDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5342839-A | Useful for therapy of oxygen deficiency diseases of the brain | BASF AKTIENGESELLSCHAFT (DE) | 1994-08-30 | — | — | US | disclosed |
| WO-1990003371-A1 | 2-HYDROXY-3-PHENOXY-PROPYL-SUBSTITUTED PIPERAZINES AND HOMOPIPERAZINES, THEIR MANUFACTURE AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1990-04-05 | — | — | WO | disclosed |