Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MLNR | O43193 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9187274 | 0.90 | MAPT (0.60) | MAPTTSHRKMT2ACACNA1GMEN1 | |
| SCHEMBL9300891 | 0.89 | TSHR (0.64) | MAPTTSHRLMNAKMT2ACACNA1G | |
| SCHEMBL9301602 | 0.89 | TSHR (0.64) | MAPTTSHRLMNAKMT2ACACNA1G | |
| SCHEMBL9301397 | 0.86 | MAPT (0.57) | MAPTTSHRKMT2ACACNA1GMEN1 | |
| SCHEMBL9301460 | 0.86 | CACNA1G (0.62) | MAPTTSHRKMT2ACACNA1GMEN1 | |
| SCHEMBL10379764 | 0.85 | L3MBTL1 (0.62) | MAPTTSHRKMT2ACACNA1GMEN1 | |
| SCHEMBL9193205 | 0.85 | L3MBTL1 (0.59) | MAPTTSHRKMT2ACACNA1GMEN1 | |
| SCHEMBL9271436 | 0.85 | CACNA1G (0.67) | MAPTTSHRKMT2ACACNA1GMEN1 | |
| SCHEMBL9189672 | 0.83 | CACNA1G (0.60) | MAPTKMT2ACACNA1GMEN1USP2 | |
| SCHEMBL9301222 | 0.83 | MAPT (0.53) | MAPTTSHRKMT2ACACNA1GMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5342839-A | Useful for therapy of oxygen deficiency diseases of the brain | BASF AKTIENGESELLSCHAFT (DE) | 1994-08-30 | — | — | US | disclosed |
| EP-0435902-A1 | 2-HYDROXY-3-PHENOXY-PROPYL-SUBSTITUTED PIPERAZINES AND HOMOPIPERAZINES, THEIR MANUFACTURE AND USE. | BASF AG (DE) | 1991-07-10 | — | — | EP | disclosed |
| WO-1990003371-A1 | 2-HYDROXY-3-PHENOXY-PROPYL-SUBSTITUTED PIPERAZINES AND HOMOPIPERAZINES, THEIR MANUFACTURE AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1990-04-05 | — | — | WO | disclosed |