Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
| ▸ | CASP6 | P55212 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300537 | 0.78 | DPP4 (0.32) | KDM4EMEN1KMT2A | |
| SCHEMBL9304641 | 0.74 | CDK2 (0.39) | CDK2CCNA2CCNA1CDK1CDK4 | |
| SCHEMBL8723623 | 0.72 | RXFP1 (0.62) | CDK2CCNA2CCNA1CASP6CDK1 | |
| SCHEMBL9663306 | 0.68 | S100B (0.32) | KDM4E | |
| SCHEMBL17447368 | 0.66 | CDK2 (0.70) | CDK2CCNA2CCNA1CDK1CDK4 | |
| SCHEMBL16464949 | 0.63 | CDK2 (1.00) | CDK2CCNA2CCNA1CDK1CDK4 | |
| SCHEMBL22927782 | 0.62 | TP53 (0.38) | RXFP1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL4193697 | 0.62 | CASP6 (0.66) | CASP6RXFP1KDM4EMEN1MAPT | |
| SCHEMBL28456121 | 0.61 | KMT2A (0.60) | RXFP1MEN1KMT2A | |
| SCHEMBL14490772 | 0.60 | CDK2 (0.47) | CDK2CCNA2CCNA1CASP6CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314890-A | Treatment of asthma | MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A. (IT) | 1994-05-24 | — | — | US | disclosed |
| EP-0531349-A1 | 1-7 SUBSTITUTED XANTHINE DERIVATIVES HAVING ANTIASTHMATIC ACTIVITY, THEIR SALTS PHYSIOLOGICALLY ACCEPTABLE, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | MALESCI ISTITUTO FARMACOBIOLOGICO S.p.A. (IT) | 1993-03-17 | — | — | EP | disclosed |
| WO-1991017993-A1 | 1-7 SUBSTITUTED XANTHINE DERIVATIVES HAVING ANTIASTHMATIC ACTIVITY, THEIR SALTS PHYSIOLOGICALLY ACCEPTABLE, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A (IT) | 1991-11-28 | — | — | WO | disclosed |