SCHEMBL9304641

SCHEMBL9304641

C=CCn1c(OC)nc(N)c(N=O)c1=O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 2/20 0.39
CCNA2 P20248 1/20 0.39
CCNA1 P78396 1/20 0.39
GRK6 P43250 1/20 0.34
POLB P06746 1/20 0.34
ALDH1A1 P00352 4/20 0.33
KDM4E B2RXH2 3/20 0.33
HTT P42858 2/20 0.33
LMNA P02545 2/20 0.33
CYP3A4 P08684 1/20 0.33
MAPT P10636 2/20 0.33
USP2 O75604 1/20 0.32
HPGD P15428 2/20 0.32
GLA P06280 1/20 0.32
GAA P10253 1/20 0.32
THRB P10828 1/20 0.32
HIF1A Q16665 1/20 0.32
TSHR P16473 1/20 0.32
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9303572 0.82 CYP3A4 (0.37) GRK6POLBALDH1A1KDM4EHTT
SCHEMBL9501414 0.81 GRK6 (0.34) GRK6POLBALDH1A1KDM4EHTT
SCHEMBL9301495 0.74 CDK2 (0.46) CDK2CCNA2CCNA1KDM4EMAPT
SCHEMBL9305415 0.70 ALDH1A1 (0.44) GRK6POLBALDH1A1KDM4EHTT
SCHEMBL6571379 0.68 CYP3A4 (0.50) ALDH1A1KDM4ECYP3A4MAPTUSP2
SCHEMBL2778902 0.67 CYP3A4 (0.44) POLBKDM4ECYP3A4MAPTUSP2
SCHEMBL9308358 0.65 ADORA2B (0.52) CDK2CCNA2CCNA1POLBALDH1A1
SCHEMBL9308527 0.65 ADORA2B (0.45) POLBALDH1A1KDM4EHTTLMNA
SCHEMBL3980944 0.63 MEN1 (0.45) ALDH1A1HTTLMNACYP3A4MAPT
SCHEMBL8505340 0.62 GAA (0.42) POLBALDH1A1KDM4EHTTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5314890-A Treatment of asthma MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A. (IT) 1994-05-24 US disclosed
EP-0531349-A1 1-7 SUBSTITUTED XANTHINE DERIVATIVES HAVING ANTIASTHMATIC ACTIVITY, THEIR SALTS PHYSIOLOGICALLY ACCEPTABLE, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION MALESCI ISTITUTO FARMACOBIOLOGICO S.p.A. (IT) 1993-03-17 EP disclosed
WO-1991017993-A1 1-7 SUBSTITUTED XANTHINE DERIVATIVES HAVING ANTIASTHMATIC ACTIVITY, THEIR SALTS PHYSIOLOGICALLY ACCEPTABLE, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A (IT) 1991-11-28 WO disclosed