Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | GALR3 | O60755 | 2/20 | 0.53 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10475504 | 0.81 | TSHR (0.60) | TP53RXFP1LMNATSHRHTT | |
| SCHEMBL9302136 | 0.79 | HDAC1 (0.72) | TP53HDAC1HDAC6LMNATSHR | |
| SCHEMBL15567387 | 0.77 | TP53 (0.54) | TP53RXFP1ALDH1A1HRH3 | |
| SCHEMBL9302826 | 0.77 | PTAFR (0.83) | PTAFRHDAC1HDAC6TNFGALR3 | |
| SCHEMBL9301610 | 0.76 | PTAFR (1.00) | PTAFRHDAC1HDAC6TNFGALR3 | |
| SCHEMBL9303746 | 0.74 | PTAFR (0.67) | PTAFRHDAC1HDAC6TSHRALDH1A1 | |
| SCHEMBL9303757 | 0.74 | PTAFR (0.78) | PTAFRHDAC1HDAC6TNFGALR3 | |
| SCHEMBL9302834 | 0.74 | PTAFR (1.00) | PTAFRHDAC1HDAC6LMNAALDH1A1 | |
| SCHEMBL507837 | 0.73 | ALDH1A1 (0.90) | HDAC6LMNAHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL1331422 | 0.73 | HDAC1 (0.74) | PTAFRHDAC1HDAC6ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314880-A | Platelet activating factor antagonist | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1994-05-24 | — | — | US | disclosed |
| EP-0468971-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |
| WO-1990009997-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1990-09-07 | — | — | WO | disclosed |