SCHEMBL9302834

SCHEMBL9302834

Cc1nc2ccccc2n1Cc1ccc(S(=O)(=O)N(C)C2CCCCC2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PTAFR P25105 2/20 1.00
HRH3 Q9Y5N1 6/20 0.53
ALDH1A1 P00352 2/20 0.52
TNF P01375 1/20 0.52
KDM4E B2RXH2 1/20 0.52
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52
GALR3 O60755 2/20 0.52
NR2F2 P24468 2/20 0.52
RAB9A P51151 1/20 0.52
CYP2D6 P10635 2/20 0.50
HRH1 P35367 2/20 0.50
CHRM1 P11229 1/20 0.50
PTGDR2 Q9Y5Y4 1/20 0.49
HDAC1 Q13547 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
KCNH2 Q12809 1/20 0.47
LMNA P02545 1/20 0.46
GAA P10253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9302509 0.91 PTAFR (0.83) PTAFRHRH3TNFGALR3NR2F2
SCHEMBL9302693 0.89 PTAFR (0.80) PTAFRHRH3ALDH1A1KDM4EMEN1
SCHEMBL9301338 0.88 PTAFR (0.78) PTAFRALDH1A1KDM4EMEN1KMT2A
SCHEMBL9303630 0.87 PTAFR (0.77) PTAFRALDH1A1KDM4EMEN1KMT2A
SCHEMBL9302507 0.87 PTAFR (0.77) PTAFRHRH3ALDH1A1KDM4EMEN1
SCHEMBL9303479 0.87 PTAFR (0.76) PTAFRALDH1A1KDM4EMEN1KMT2A
SCHEMBL9304261 0.86 PTAFR (0.75) PTAFRHRH3ALDH1A1KDM4EMEN1
SCHEMBL9302097 0.84 PTAFR (0.72) PTAFRALDH1A1KDM4EMEN1KMT2A
SCHEMBL9303746 0.80 PTAFR (0.67) PTAFRHRH3ALDH1A1TNFKDM4E
SCHEMBL9302023 0.79 PTAFR (0.66) PTAFRHRH3ALDH1A1TNFGALR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1990009997-A1 NOVEL BENZIMIDAZOLE DERIVATIVES BRITISH BIO-TECHNOLOGY LIMITED (GB) 1990-09-07 WO claimed
US-20260022130-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2026-01-22 US disclosed
US-12281124-B2 Heterocyclic compounds as monoacylglycerol lipase inhibitors HOFFMANN-LA ROCHE INC. (US) 2025-04-22 US disclosed
WO-2025075089-A1 BIARYL COMPOUND AND METHOD FOR CONTROLLING PLANT DISEASE 住友化学株式会社 2025-04-10 WO disclosed
EP-4474017-A2 NEW HETEROCYCLIC COMPOUNDS F. Hoffmann-La Roche AG (CH) 2024-12-11 EP disclosed
US-20240277796-A1 METHODS FOR INHIBITING RAS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2024-08-22 US disclosed
US-20240277714-A1 USE OF SOS1 INHIBITORS WITH RAS INHIBITORS TO TREAT CANCERS Revolution Medicines, Inc. 2024-08-22 US disclosed
EP-3837263-B1 NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN LA ROCHE (CH) 2024-07-03 EP disclosed
US-20240150373-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2024-05-09 US disclosed
US-20240108630-A1 METHODS FOR INHIBITING RAS Revolution Medicines, Inc. 2024-04-04 US disclosed
US-11802133-B2 Heterocyclic compounds as monoacylglycerol lipase inhibitors HOFFMANN-LA ROCHE INC. (US) 2023-10-31 US disclosed
EP-4223755-A1 HETEROCYCLIC COMPOUND AND HARMFUL ARTHROPOD-CONTROLLING COMPOSITION INCLUDING SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2023-08-09 EP disclosed
CN-116456817-A Heterocyclic compound and harmful arthropod control composition containing same 住友化学株式会社 2023-07-18 CN disclosed
US-20230050901-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2023-02-16 US disclosed
EP-3911716-B1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2022-09-21 EP disclosed
CN-114436942-A Arylamine compound containing carbazole group and organic electroluminescent device thereof 长春海谱润斯科技股份有限公司 2022-05-06 CN disclosed
WO-2022071428-A1 HETEROCYCLIC COMPOUND AND HARMFUL ARTHROPOD-CONTROLLING COMPOSITION INCLUDING SAME 住友化学株式会社 2022-04-07 WO disclosed
US-5314880-A Platelet activating factor antagonist BRITISH BIO-TECHNOLOGY LIMITED (GB) 1994-05-24 US disclosed
EP-0468971-A1 NOVEL BENZIMIDAZOLE DERIVATIVES BRITISH BIO-TECHNOLOGY LIMITED (GB) 1992-02-05 EP disclosed
WO-1990009997-A1 NOVEL BENZIMIDAZOLE DERIVATIVES BRITISH BIO-TECHNOLOGY LIMITED (GB) 1990-09-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260022130-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS LIPC, LIPA, LPL PTAFR 3847/4885HRH3 988/4885ALDH1A1 1338/4885
US-12281124-B2 Heterocyclic compounds as monoacylglycerol lipase inhibitors LIPC, LPL, MGLL PTAFR 1775/4885HRH3 2629/4885ALDH1A1 525/4885
US-20240150373-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS LIPC, LPL, MGLL PTAFR 1775/4885HRH3 2629/4885ALDH1A1 525/4885
US-20240277714-A1 USE OF SOS1 INHIBITORS WITH RAS INHIBITORS TO TREAT CANCERS SOS1, HRAS, KRAS PTAFR 3093/4885HRH3 3334/4885ALDH1A1 4139/4885
US-11802133-B2 Heterocyclic compounds as monoacylglycerol lipase inhibitors LIPC, LPL, MGLL PTAFR 1775/4885HRH3 2629/4885ALDH1A1 525/4885
US-20240277796-A1 METHODS FOR INHIBITING RAS KRAS, HRAS, NRAS PTAFR 2774/4885HRH3 3469/4885ALDH1A1 4355/4885
US-20230050901-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS LIPC, LPL, MGLL PTAFR 1775/4885HRH3 2629/4885ALDH1A1 525/4885
US-20240108630-A1 METHODS FOR INHIBITING RAS KRAS, HRAS, NRAS PTAFR 2740/4885HRH3 3475/4885ALDH1A1 4098/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.