Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9302642 | 0.87 | ALDH1A1 (0.54) | POLBRXFP1ALDH1A1HTTLMNA | |
| SCHEMBL9302598 | 0.86 | NR1H3 (0.50) | POLBRXFP1ALDH1A1HTTLMNA | |
| SCHEMBL9302737 | 0.84 | CXCR4 (0.46) | POLBRXFP1ALDH1A1HTTLMNA | |
| SCHEMBL9302302 | 0.84 | CXCR4 (0.48) | ALDH1A1HTTLMNACNR2MAOA | |
| SCHEMBL9303027 | 0.80 | CXCR4 (0.45) | POLBRXFP1ALDH1A1HTTLMNA | |
| SCHEMBL14470052 | 0.80 | POLB (0.67) | POLBRXFP1PDE4DALDH1A1HTT | |
| SCHEMBL9672391 | 0.80 | HTT (0.48) | POLBRXFP1PDE4DALDH1A1HTT | |
| SCHEMBL9302028 | 0.73 | CA12 (0.52) | POLBALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL9303789 | 0.73 | ESR1 (0.56) | ALDH1A1HTTLMNACNR2MAPT | |
| SCHEMBL9303870 | 0.72 | CA2 (0.47) | SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990009997-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1990-09-07 | — | — | WO | claimed |
| US-5314880-A | Platelet activating factor antagonist | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1994-05-24 | — | — | US | disclosed |