Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HNF4A | P41235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9304643 | 0.85 | THRA (0.44) | GPR35SOS1CA12CA9POLB | |
| SCHEMBL9242812 | 0.83 | GRIN2D (0.44) | GPR35SOS1POLBESR1ESR2 | |
| SCHEMBL9302889 | 0.80 | ESR1 (0.41) | GPR35SMN1; SMN2DHODHNPC1RAB9A | |
| SCHEMBL9262474 | 0.76 | POLB (0.41) | GPR35SOS1POLBTHRBESR1 | |
| SCHEMBL9302205 | 0.75 | ESR1 (0.44) | GPR35CA12CA9DHODHNPC1 | |
| SCHEMBL9255419 | 0.74 | ACMSD (0.44) | ACMSDGPR35DHODH | |
| SCHEMBL9255770 | 0.74 | CYP3A4 (0.46) | GPR35LMNASMN1; SMN2DHODH | |
| SCHEMBL9303171 | 0.73 | POLB (0.43) | ACMSDGPR35SOS1POLBHCAR2 | |
| SCHEMBL9269222 | 0.73 | HSD17B1 (0.42) | GPR35SOS1CA12CA9POLB | |
| SCHEMBL9302159 | 0.72 | GPR35 (0.46) | GPR35LMNASMN1; SMN2POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |