Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9194816 | 0.86 | GABRA1 (0.40) | GABRA1GABRB2 | |
| SCHEMBL5692470 | 0.83 | GABRA1 (0.46) | GABRA1GABRB2ALOX5NFKB1NFKB2 | |
| SCHEMBL9193711 | 0.83 | GABRA1 (0.46) | GABRA1GABRB2ALOX5NFKB1NFKB2 | |
| SCHEMBL9193282 | 0.81 | DHFR (0.41) | GABRA1GABRB2ALOX5 | |
| SCHEMBL16182674 | 0.80 | GABRA1 (0.50) | GABRA1GABRB2ALOX5NFKB1NFKB2 | |
| SCHEMBL9192781 | 0.78 | HTT (0.42) | GABRA1GABRB2ALOX5ALOX15 | |
| SCHEMBL4659133 | 0.77 | NPC1 (0.48) | GABRA1GABRB2 | |
| SCHEMBL8342795 | 0.76 | GABRA1 (0.54) | GABRA1GABRB2NFKB1ALOX15ALOX12 | |
| SCHEMBL28720288 | 0.76 | PTGS2 (0.53) | GABRA1GABRB2 | |
| SCHEMBL9195415 | 0.76 | GABRA1 (0.51) | GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304668-A | Bis-[4-(2,6-di-alkyl)phenolisilane derivatives as antiatherosclerotic agents | MERRELL DOW PHARMACEUTICALS (US) | 1994-04-19 | — | — | US | disclosed |
| US-5281738-A | Anticholesterol agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-01-25 | — | — | US | disclosed |