Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9303864 | 0.81 | TSHR (0.47) | TSHRALDH1A1AOC3RIPK1NPC1 | |
| Hydrochloric Acid SCHEMBL9303560 | 0.80 | ALDH1A1 (0.45) | TSHRALDH1A1AOC3RIPK1NPC1 | |
| SCHEMBL17258048 | 0.79 | KMT2A (0.51) | TSHRALDH1A1RIPK1NPC1RAB9A | |
| SCHEMBL19954207 | 0.79 | TSHR (0.52) | TSHRALDH1A1AOC3RIPK1NPC1 | |
| SCHEMBL11249019 | 0.76 | TSHR (0.54) | TSHRALDH1A1AOC3RIPK1NPC1 | |
| SCHEMBL1640061 | 0.76 | TSHR (0.58) | TSHRALDH1A1AOC3RIPK1NPC1 | |
| SCHEMBL31481619 | 0.74 | TSHR (0.56) | TSHRALDH1A1AOC3RIPK1NPC1 | |
| SCHEMBL9426454 | 0.74 | CHRM3 (0.47) | TSHRRIPK1NPC1RAB9ACA12 | |
| SCHEMBL9426376 | 0.73 | DRD2 (0.56) | TSHRALDH1A1RAB9ACYP3A4CYP2D6 | |
| SCHEMBL18098741 | 0.73 | RIPK1 (0.50) | TSHRALDH1A1RIPK1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0505379-B1 | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LTD (GB) | 1994-07-20 | — | — | EP | disclosed |
| US-5302595-A | Muscarinic receptor antagonists | PFIZER INC. (US) | 1994-04-12 | — | — | US | disclosed |
| US-5300516-A | Muscarinic receptor antagonists | PFIZER INC. (US) | 1994-04-05 | — | — | US | disclosed |
| US-5219871-A | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1993-06-15 | — | — | US | disclosed |
| EP-0505379-A1 | MUSCARINIC RECEPTOR ANTAGONISTS. | PFIZER LTD (GB) | 1992-09-30 | — | — | EP | disclosed |
| WO-1991009014-A1 | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 1991-06-27 | — | — | WO | disclosed |
| EP-0364123-B1 | MUSCARINIC RECEPTOR ANTAGONISTS | Pfizer Limited (GB) | 1991-06-12 | — | — | EP | disclosed |
| EP-0364123-A1 | Muscarinic receptor antagonists | Pfizer Limited (GB) | 1990-04-18 | — | — | EP | disclosed |