Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 11/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | GPR174 | Q9BXC1 | 7/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301332 | 0.90 | MAPT (0.64) | LMNAGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4365700 | 0.77 | MAPT (0.66) | LMNAGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL16513593 | 0.76 | MAPT (0.76) | LMNAGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL29847854 | 0.76 | MAPT (0.76) | LMNAGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9301104 | 0.76 | ALDH1A1 (0.43) | GAAMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL30679042 | 0.76 | MAPT (0.71) | LMNAGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8103160 | 0.74 | MAPT (0.62) | LMNAGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9427619 | 0.74 | ESPL1 (0.40) | LMNAGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL23293826 | 0.74 | MAPT (0.67) | LMNAGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL22652238 | 0.73 | MAPT (0.76) | LMNAGAAMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283248-A | Bactericides, enzyme inhibitor of DNA-gyrase in bacteria | HOFFMANN-LA ROCHE INC. (US) | 1994-02-01 | — | — | US | disclosed |
| EP-0433648-A1 | Substituted pyrimidobenzimidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-26 | — | — | EP | disclosed |