SCHEMBL9301104

SCHEMBL9301104

CCN(C(C)=O)c1cc(Cl)c(F)cc1[N+](=O)[O-]

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
SLC6A4 P31645 1/20 0.40
HCAR3 P49019 4/20 0.40
VCAM1 P19320 6/20 0.37
GAA P10253 1/20 0.36
HPGD P15428 1/20 0.36
KDM4E B2RXH2 1/20 0.35
ALDH3A1 P30838 1/20 0.35
HTT P42858 2/20 0.35
TP53 P04637 1/20 0.35
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34
MAPT P10636 1/20 0.34
MAPK1 P28482 1/20 0.34
RAB9A P51151 1/20 0.34
KMT2A Q03164 1/20 0.34
ADORA2A P29274 1/20 0.34
ADORA2B P29275 1/20 0.34
ADORA1 P30542 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9427619 0.82 ESPL1 (0.40) ALDH1A1SMN1; SMN2HCAR3GAAKDM4E
SCHEMBL15248395 0.77 HCAR3 (0.45) ALDH1A1SMN1; SMN2HCAR3GAAKDM4E
SCHEMBL9847872 0.76 GPR174 (0.37) ALDH1A1SMN1; SMN2SLC6A4HCAR3VCAM1
SCHEMBL9303493 0.76 LMNA (0.60) ALDH1A1SMN1; SMN2GAAMEN1MAPT
SCHEMBL9301332 0.75 MAPT (0.64) ALDH1A1SMN1; SMN2GAAHTTMEN1
SCHEMBL4706313 0.75 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2HCAR3VCAM1GAA
SCHEMBL4706308 0.75 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2HCAR3VCAM1GAA
SCHEMBL31208163 0.74 ALDH1A1 (0.68) ALDH1A1SMN1; SMN2SLC6A4HCAR3VCAM1
SCHEMBL7545601 0.73 ALDH3A1 (0.46) ALDH1A1SMN1; SMN2SLC6A4HCAR3VCAM1
SCHEMBL10686076 0.72 HTT (0.55) ALDH1A1HCAR3GAAHPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5283248-A Bactericides, enzyme inhibitor of DNA-gyrase in bacteria HOFFMANN-LA ROCHE INC. (US) 1994-02-01 US disclosed
EP-0433648-A1 Substituted pyrimidobenzimidazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 1991-06-26 EP disclosed