Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD2 | Q15562 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9304621 | 0.96 | TEAD2 (0.43) | TEAD2HRH1CYP3A4KDM4EHSD17B10 | |
| SCHEMBL9303594 | 0.93 | HRH1 (0.36) | TEAD2HRH1CYP3A4KDM4EHSD17B10 | |
| Maleic Acid SCHEMBL8138730 | 0.91 | TEAD2 (0.40) | TEAD2KDM4EHSD17B10TSHRESR1 | |
| Fumaric Acid SCHEMBL8138733 | 0.91 | TEAD2 (0.40) | TEAD2KDM4EHSD17B10TSHRESR1 | |
| SCHEMBL8135725 | 0.88 | LTA4H (0.39) | CYP3A4KDM4EHSD17B10ALDH1A1TSHR | |
| SCHEMBL9304792 | 0.85 | MAPK13 (0.41) | KDM4EHSD17B10TSHRMERTKMAPK13 | |
| SCHEMBL9305127 | 0.84 | MERTK (0.41) | CYP3A4KDM4EHSD17B10ALDH1A1TSHR | |
| Maleic Acid SCHEMBL8135697 | 0.84 | TEAD2 (0.37) | TEAD2KDM4EHSD17B10TSHRNAMPT | |
| Fumaric Acid SCHEMBL8135703 | 0.84 | TEAD2 (0.37) | TEAD2KDM4EHSD17B10TSHRNAMPT | |
| SCHEMBL9305096 | 0.83 | KDM4E (0.38) | CYP3A4KDM4EHSD17B10ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296491-A | Pyrazolo[4,3-c]pyridines and their use as serotonin reuptake inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-22 | — | — | US | claimed |