Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 6/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 2/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9304408 | 0.85 | P2RY14 (0.42) | ALOX5P2RY14MAOBACHECASP3 | |
| SCHEMBL9303279 | 0.84 | ALOX5 (0.41) | ALOX5P2RY14MAOBACHECASP3 | |
| SCHEMBL9303192 | 0.82 | P2RY14 (0.41) | ALOX5P2RY14MEN1KMT2AMAOB | |
| SCHEMBL9303851 | 0.73 | ALOX5 (0.45) | ALOX5P2RY14NPC1RAB9AMEN1 | |
| SCHEMBL9303261 | 0.67 | P2RY14 (0.57) | ALOX5P2RY14MEN1KMT2AMAOB | |
| SCHEMBL9302917 | 0.65 | P2RY14 (0.55) | ALOX5P2RY14MEN1KMT2AMAOB | |
| SCHEMBL9301873 | 0.65 | ALOX5 (0.68) | ALOX5P2RY14MAOBMAOA | |
| SCHEMBL9302951 | 0.64 | P2RY14 (0.56) | ALOX5P2RY14MAOBACHECASP3 | |
| SCHEMBL6825691 | 0.63 | MAOB (0.52) | ALOX5NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9301064 | 0.63 | ALOX5 (0.51) | ALOX5P2RY14NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |