Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 9/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9305694 | 0.93 | TDP1 (0.37) | P2RX7PTPN11TRPA1SIGMAR1TOP2A | |
| Fumaric Acid SCHEMBL8136680 | 0.91 | RORC (0.35) | P2RX7PTPN11TRPA1SIGMAR1TOP2A | |
| Fumaric Acid SCHEMBL8136684 | 0.91 | RORC (0.35) | P2RX7PTPN11TRPA1SIGMAR1TOP2A | |
| SCHEMBL8134219 | 0.90 | CDC7 (0.41) | P2RX7TOP2AKCNA5CDC7CDK2 | |
| SCHEMBL9303598 | 0.89 | P2RX7 (0.36) | P2RX7MAOARORC | |
| SCHEMBL9304139 | 0.86 | TOP2A (0.39) | TOP2ACDC7CDK2MAOARORC | |
| Fumaric Acid SCHEMBL8143970 | 0.84 | KDM4E (0.36) | P2RX7PTPN11TOP2AKCNA5CDC7 | |
| Fumaric Acid SCHEMBL8143969 | 0.84 | KDM4E (0.36) | P2RX7PTPN11TOP2AKCNA5CDC7 | |
| SCHEMBL9304250 | 0.83 | TDP1 (0.41) | TOP2AKCNA5CDC7CDK2MAOA | |
| SCHEMBL8137244 | 0.82 | P2RX7 (0.34) | P2RX7CYP2D6MAOAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296491-A | Pyrazolo[4,3-c]pyridines and their use as serotonin reuptake inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-22 | — | — | US | claimed |